Small nerve fiber involvement in patients referred for fibromyalgia

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Fibromyalgia (FM) is a chronic syndrome characterized by widespread pain often accompanied by other symptoms suggestive of neuropathic pain. We evaluated patients for small fiber neuropathy (SFN) who were referred for fibromyalgia (FM). Methods: We studied 20 consecutive subjects with primary FM. Patients underwent neurological examination, nerve conduction studies, and skin biopsies from distal leg and thigh. Results: Electrodiagnostic studies were normal in all patients. SFN was diagnosed in 6 patients by reduced epidermal nerve fiber density. These patients also showed abnormalities of both adrenergic and cholinergic fibers. Conclusions: A subset of FM subjects have SFN, which may contribute to their sensory and autonomic symptoms. Skin biopsy should be considered in the diagnostic work-up of FM.

Original languageEnglish
Pages (from-to)757-759
Number of pages3
JournalMuscle and Nerve
Volume49
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Autonomic dysfunction
  • Fibromyalgia
  • Neuropathic pain
  • Skin biopsy
  • Small fiber neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

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