Small-vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculitis of the temporal artery: Two subsets of giant cell arteritis

Giovanna Restuccia, Alberto Cavazza, Luigi Boiardi, Nicolã Pipitone, Pierluigi MacChioni, Gianluigi Bajocchi, Maria Grazia Catanoso, Francesco Muratore, Alessandra Ghinoi, Luca Magnani, Luca Cimino, Carlo Salvarani

Research output: Contribution to journalArticle

Abstract

Objective To evaluate the frequency and clinical characteristics of periadventitial small-vessel vasculitis (SVV) and isolated vasa vasorum vasculitis (VVV). Methods We identified 455 temporal artery biopsies performed in residents of Reggio Emilia, Italy between 1986 and 2003. Slides of temporal artery biopsy specimens were reviewed by a pathologist who was blinded with regard to clinical data. SVV was defined as inflammation of the small vessels external to the temporal artery adventitia, and VVV was defined as isolated inflammation of temporal artery vasa vasorum. Medical records of patients with SVV and/or VVV were reviewed, and demographic, clinical, laboratory, and followup data were collected. For comparison purposes, we collected the same data from an equal number of randomly selected patients with evidence of classic giant cell arteritis (GCA). Results Sixteen patients had SVV, 18 had isolated VVV, and 5 had both SVV and VVV. Compared with patients with classic GCA, the frequencies of headache, scalp tenderness, abnormalities of temporal arteries, jaw claudication, anorexia, and weight loss, the levels of acute-phase reactant at diagnosis, and the initial and cumulative doses prednisone were significantly lower and the frequency of peripheral synovitis was higher in the patients with SVV, and the frequency of cranial ischemic events was similar in the 2 groups. In contrast, the clinical characteristics and erythrocyte sedimentation rate at diagnosis of patients with isolated VVV were similar to those of patients with classic GCA. Conclusion Our findings indicate that isolated VVV and SVV should be considered part of the histopathologic spectrum of GCA.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalArthritis and Rheumatism
Volume64
Issue number2
DOIs
Publication statusPublished - Feb 2012

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Vasa Vasorum
Temporal Arteries
Giant Cell Arteritis
Vasculitis
Inflammation
Biopsy
Adventitia
Synovitis
Acute-Phase Proteins
Blood Sedimentation
Anorexia

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Rheumatology
  • Pharmacology (medical)

Cite this

Small-vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculitis of the temporal artery : Two subsets of giant cell arteritis. / Restuccia, Giovanna; Cavazza, Alberto; Boiardi, Luigi; Pipitone, Nicolã; MacChioni, Pierluigi; Bajocchi, Gianluigi; Catanoso, Maria Grazia; Muratore, Francesco; Ghinoi, Alessandra; Magnani, Luca; Cimino, Luca; Salvarani, Carlo.

In: Arthritis and Rheumatism, Vol. 64, No. 2, 02.2012, p. 549-556.

Research output: Contribution to journalArticle

Restuccia, G, Cavazza, A, Boiardi, L, Pipitone, N, MacChioni, P, Bajocchi, G, Catanoso, MG, Muratore, F, Ghinoi, A, Magnani, L, Cimino, L & Salvarani, C 2012, 'Small-vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculitis of the temporal artery: Two subsets of giant cell arteritis', Arthritis and Rheumatism, vol. 64, no. 2, pp. 549-556. https://doi.org/10.1002/art.33362
Restuccia, Giovanna ; Cavazza, Alberto ; Boiardi, Luigi ; Pipitone, Nicolã ; MacChioni, Pierluigi ; Bajocchi, Gianluigi ; Catanoso, Maria Grazia ; Muratore, Francesco ; Ghinoi, Alessandra ; Magnani, Luca ; Cimino, Luca ; Salvarani, Carlo. / Small-vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculitis of the temporal artery : Two subsets of giant cell arteritis. In: Arthritis and Rheumatism. 2012 ; Vol. 64, No. 2. pp. 549-556.
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abstract = "Objective To evaluate the frequency and clinical characteristics of periadventitial small-vessel vasculitis (SVV) and isolated vasa vasorum vasculitis (VVV). Methods We identified 455 temporal artery biopsies performed in residents of Reggio Emilia, Italy between 1986 and 2003. Slides of temporal artery biopsy specimens were reviewed by a pathologist who was blinded with regard to clinical data. SVV was defined as inflammation of the small vessels external to the temporal artery adventitia, and VVV was defined as isolated inflammation of temporal artery vasa vasorum. Medical records of patients with SVV and/or VVV were reviewed, and demographic, clinical, laboratory, and followup data were collected. For comparison purposes, we collected the same data from an equal number of randomly selected patients with evidence of classic giant cell arteritis (GCA). Results Sixteen patients had SVV, 18 had isolated VVV, and 5 had both SVV and VVV. Compared with patients with classic GCA, the frequencies of headache, scalp tenderness, abnormalities of temporal arteries, jaw claudication, anorexia, and weight loss, the levels of acute-phase reactant at diagnosis, and the initial and cumulative doses prednisone were significantly lower and the frequency of peripheral synovitis was higher in the patients with SVV, and the frequency of cranial ischemic events was similar in the 2 groups. In contrast, the clinical characteristics and erythrocyte sedimentation rate at diagnosis of patients with isolated VVV were similar to those of patients with classic GCA. Conclusion Our findings indicate that isolated VVV and SVV should be considered part of the histopathologic spectrum of GCA.",
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AU - Boiardi, Luigi

AU - Pipitone, Nicolã

AU - MacChioni, Pierluigi

AU - Bajocchi, Gianluigi

AU - Catanoso, Maria Grazia

AU - Muratore, Francesco

AU - Ghinoi, Alessandra

AU - Magnani, Luca

AU - Cimino, Luca

AU - Salvarani, Carlo

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N2 - Objective To evaluate the frequency and clinical characteristics of periadventitial small-vessel vasculitis (SVV) and isolated vasa vasorum vasculitis (VVV). Methods We identified 455 temporal artery biopsies performed in residents of Reggio Emilia, Italy between 1986 and 2003. Slides of temporal artery biopsy specimens were reviewed by a pathologist who was blinded with regard to clinical data. SVV was defined as inflammation of the small vessels external to the temporal artery adventitia, and VVV was defined as isolated inflammation of temporal artery vasa vasorum. Medical records of patients with SVV and/or VVV were reviewed, and demographic, clinical, laboratory, and followup data were collected. For comparison purposes, we collected the same data from an equal number of randomly selected patients with evidence of classic giant cell arteritis (GCA). Results Sixteen patients had SVV, 18 had isolated VVV, and 5 had both SVV and VVV. Compared with patients with classic GCA, the frequencies of headache, scalp tenderness, abnormalities of temporal arteries, jaw claudication, anorexia, and weight loss, the levels of acute-phase reactant at diagnosis, and the initial and cumulative doses prednisone were significantly lower and the frequency of peripheral synovitis was higher in the patients with SVV, and the frequency of cranial ischemic events was similar in the 2 groups. In contrast, the clinical characteristics and erythrocyte sedimentation rate at diagnosis of patients with isolated VVV were similar to those of patients with classic GCA. Conclusion Our findings indicate that isolated VVV and SVV should be considered part of the histopathologic spectrum of GCA.

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