Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in Northern Italy

Silvia Franceschi, Renato Talamini, Salvatore Barra, Anna E. Barón, Eva Negri, Ettore Bidoli, Diego Serraino, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

A hospital-based case-control study of upper aerodigestive tract tumors was conducted between June 1986 and June 1989 in Northern Italy. One hundred fifty-seven male cases of oral cavity cancer, 134 of pharyngeal cancer, 162 of laryngeal cancer, and 288 of esophageal cancer, and 1272 male inpatients with acute conditions unrelated to tobacco and alcohol were interviewed. Odds ratios for current smokers of cigarettes were 11.1 for oral cavity, 12.9 for pharynx, 4.6 for larynx, and 3.8 for esophagus. For all 4 sites, the risk increased with increasing number of cigarettes and duration of smoking habits and, with the exception of esophageal cancer, decreased with increasing age at the start of and years since quitting smoking. Smokers of pipes and cigars showed a more elevated risk of cancer of the oral cavity and esophagus than did cigarette smokers. Significantly increased risks emerged also in heavy drinkers (odds ratio >60 versus ≥19 drinks/week = 3.4, 3.6, 2.1, and 6.0 for oral cavity, pharynx, larynx, and esophagus, respectively), deriving predominantly from wine consumption.

Original languageEnglish
Pages (from-to)6502-6507
Number of pages6
JournalCancer Research
Volume50
Issue number20
Publication statusPublished - Oct 15 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Franceschi, S., Talamini, R., Barra, S., Barón, A. E., Negri, E., Bidoli, E., Serraino, D., & La Vecchia, C. (1990). Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in Northern Italy. Cancer Research, 50(20), 6502-6507.