Smoking and hematolymphopoietic malignancies

E. Stagnaro, V. Ramazzotti, P. Crosignani, A. Fontana, G. Masala, L. Miligi, O. Nanni, M. Neri, S. Rodella, A. S. Costantini, R. Tumino, C. Viganò, C. Vindigni, P. Vineis

Research output: Contribution to journalArticle

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Abstract

Objective: Tobacco use is the most prominent cause of respiratory cancers. Little is known, however, about the influence of smoking on hematolymphopoietic malignancies. To evaluate this relation, a population-based case-control study was carried out in 12 areas of Italy. Methods: Detailed interviews on tobacco smoking habits were administered to 1450 non-Hodgkin's lymphoma (NHL), 365 Hodgkin's disease (HD), 270 multiple myeloma (MM), and 649 leukemia (LEU) patients occurring from 1990 to 1993, and 1779 population controls. Results: We found a slightly increased risk for NHL in smokers (odds ratio 1.2, 95% confidence interval 1.0-1.4 for ever smokers), but a consistent positive association was shown only for follicular NHL. In this subtype, a significant excess risk was observed for ever versus never smokers, after adjustment for gender, age, geographic residence, education, and respondent (OR = 1.8, 95%, CI 1.3-2.7), with a positive exposure-response gradient for smoking duration (p <0.01). The risk for follicular NHL was significantly elevated only among women, with ever smokers showing OR = 2.3 (CI 1.4-3.8), while for men we found OR = 1.3 (CI 0.69-2.3). No major differences were shown according to age. Female subjects also showed significant positive exposure-response trends for duration. Conclusion: Cigarette smoking could be a risk factor for follicular NHL among women. For HD, MM, or LEU, no clear association was observed.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalCancer Causes and Control
Volume12
Issue number4
DOIs
Publication statusPublished - 2001

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Non-Hodgkin's Lymphoma
Smoking
Follicular Lymphoma
Neoplasms
Multiple Myeloma
Hodgkin Disease
Leukemia
Population Control
Tobacco Use
Italy
Habits
Case-Control Studies
Odds Ratio
Confidence Intervals
Interviews
Education
Population

Keywords

  • Case-control studies
  • Leukemia
  • Lymphoma
  • Multiple myeloma
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Stagnaro, E., Ramazzotti, V., Crosignani, P., Fontana, A., Masala, G., Miligi, L., ... Vineis, P. (2001). Smoking and hematolymphopoietic malignancies. Cancer Causes and Control, 12(4), 325-334. https://doi.org/10.1023/A:1011216102871

Smoking and hematolymphopoietic malignancies. / Stagnaro, E.; Ramazzotti, V.; Crosignani, P.; Fontana, A.; Masala, G.; Miligi, L.; Nanni, O.; Neri, M.; Rodella, S.; Costantini, A. S.; Tumino, R.; Viganò, C.; Vindigni, C.; Vineis, P.

In: Cancer Causes and Control, Vol. 12, No. 4, 2001, p. 325-334.

Research output: Contribution to journalArticle

Stagnaro, E, Ramazzotti, V, Crosignani, P, Fontana, A, Masala, G, Miligi, L, Nanni, O, Neri, M, Rodella, S, Costantini, AS, Tumino, R, Viganò, C, Vindigni, C & Vineis, P 2001, 'Smoking and hematolymphopoietic malignancies', Cancer Causes and Control, vol. 12, no. 4, pp. 325-334. https://doi.org/10.1023/A:1011216102871
Stagnaro E, Ramazzotti V, Crosignani P, Fontana A, Masala G, Miligi L et al. Smoking and hematolymphopoietic malignancies. Cancer Causes and Control. 2001;12(4):325-334. https://doi.org/10.1023/A:1011216102871
Stagnaro, E. ; Ramazzotti, V. ; Crosignani, P. ; Fontana, A. ; Masala, G. ; Miligi, L. ; Nanni, O. ; Neri, M. ; Rodella, S. ; Costantini, A. S. ; Tumino, R. ; Viganò, C. ; Vindigni, C. ; Vineis, P. / Smoking and hematolymphopoietic malignancies. In: Cancer Causes and Control. 2001 ; Vol. 12, No. 4. pp. 325-334.
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AU - Miligi, L.

AU - Nanni, O.

AU - Neri, M.

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AU - Vineis, P.

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