Smoking and renal cell carcinoma

Carlo La Vecchia, Eva Negri, Barbara D'Avanzo, Silvia Franceschi

Research output: Contribution to journalArticlepeer-review


The relationship between smoking habits and the risk of renal cell carcinoma was investigated in a case-control study conducted in northern Italy on 131 cases of histologically confirmed cancers of the renal parenchyma (85 males, 46 females) and 394 controls in hospital for acute, nonneoplastic, nonurological disorders. Compared with never smokers, the relative risk (RR) was 1.7 (95% confidence interval = 1.0-3.1) among ex-smokers. A direct and significant dose-risk relationship was observed among current smokers, with RR of 1.1, 1.9, and 2.3 for moderate, intermediate, and heavy smokers. This trend in risk was statistically significant (χ2 1 = 5.04; P = 0.02). The risk was directly related with duration of smoking (RR = 1.7 for 20 years) and, among ex-smokers, with time elapsed since stopping (RR = 2.2 for

Original languageEnglish
Pages (from-to)5231-5233
Number of pages3
JournalCancer Research
Issue number17
Publication statusPublished - Sep 1 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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