Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Carlos A. González, Guillem Pera, Antonio Agudo, Domenico Palli, Vittorio Krogh, Paolo Vineis, Rosario Tumino, Salvatore Panico, Göran Berglund, Henrik Simán, Olof Nyrén, Asa Agren, Carmen Martinez, Miren Dorronsoro, Aurelio Barricarte, María J. Tormo, Jose R. Quiros, Naomi Allen, Sheila Bingham, Nicholas DayAntony Miller, Gabriele Nagel, Heiner Boeing, Kim Overvad, Anne Tjonneland, H. Bas Bueno-de-Mesquita, Hendriek C. Boshuizen, Petra Peeters, Mattijs Numans, François Clavel-Chapelon, Ishaki Helen, Emmanuel Agapitos, Eiliv Lund, Michael Fahey, Rodolfo Saracci, Rudolf Kaaks, Elio Riboli

Research output: Contribution to journalArticle

Abstract

Smoking has recently been recognised as causally associated with the development of gastric cancer (GC). However, evidence on the effect by sex, duration and intensity of smoking, anatomic subsite and cessation of smoking is limited. Our objective was to assess the relation between tobacco use and GC incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC). We studied data from 521,468 individuals recruited from 10 European countries taking part in the EPIC study. Participants completed lifestyle questionnaires that included questions on lifetime consumption of tobacco and diet in 1991-1998. Participants were followed until September 2002, and during that period 305 cases of stomach cancer were identified. After exclusions, 274 were eligible for the analysis, using the Cox proportional hazard model. After adjustment for educational level, consumption of fresh fruit, vegetables and preserved meat, alcohol intake and body mass index (BMI), there was a significant association between cigarette smoking and gastric cancer risk: the hazard ratio (HR) for ever smokers was 1.45 (95% confidence interval [CI] = 1.08-1.94). The HR of current cigarette smoking was 1.73 (95% CI = 1.06-2.83) in males and 1.87 (95% CI = 1.12-3.12) in females. Hazard ratios increased with intensity and duration of cigarette smoked. A significant decrease of risk was observed after 10 years of quitting smoking. A preliminary analysis of 121 cases with identified anatomic site showed that current cigarette smokers had a higher HR of GC in the cardia (HR = 4.10) than in the distal part of the stomach (HR = 1.94). In this cohort, 17.6 % (95% CI = 10.5-29.5 %) of GC cases may be attributable to smoking. Findings from this large study support the causal relation between smoking and gastric cancer in this European population. Stomach cancer should be added to the burden of diseases caused by smoking.

Original languageEnglish
Pages (from-to)629-634
Number of pages6
JournalInternational Journal of Cancer
Volume107
Issue number4
DOIs
Publication statusPublished - Nov 20 2003

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Stomach Neoplasms
Smoking
Neoplasms
Confidence Intervals
Tobacco Use
Tobacco Products
Cardia
Smoking Cessation
Proportional Hazards Models
Vegetables
Meat
Life Style
Fruit
Stomach
Body Mass Index
Odds Ratio
Alcohols
Diet
Incidence
Population

Keywords

  • Cohort study
  • Gastric cancer
  • Smoking

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). / González, Carlos A.; Pera, Guillem; Agudo, Antonio; Palli, Domenico; Krogh, Vittorio; Vineis, Paolo; Tumino, Rosario; Panico, Salvatore; Berglund, Göran; Simán, Henrik; Nyrén, Olof; Agren, Asa; Martinez, Carmen; Dorronsoro, Miren; Barricarte, Aurelio; Tormo, María J.; Quiros, Jose R.; Allen, Naomi; Bingham, Sheila; Day, Nicholas; Miller, Antony; Nagel, Gabriele; Boeing, Heiner; Overvad, Kim; Tjonneland, Anne; Bueno-de-Mesquita, H. Bas; Boshuizen, Hendriek C.; Peeters, Petra; Numans, Mattijs; Clavel-Chapelon, François; Helen, Ishaki; Agapitos, Emmanuel; Lund, Eiliv; Fahey, Michael; Saracci, Rodolfo; Kaaks, Rudolf; Riboli, Elio.

In: International Journal of Cancer, Vol. 107, No. 4, 20.11.2003, p. 629-634.

Research output: Contribution to journalArticle

González, CA, Pera, G, Agudo, A, Palli, D, Krogh, V, Vineis, P, Tumino, R, Panico, S, Berglund, G, Simán, H, Nyrén, O, Agren, A, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, MJ, Quiros, JR, Allen, N, Bingham, S, Day, N, Miller, A, Nagel, G, Boeing, H, Overvad, K, Tjonneland, A, Bueno-de-Mesquita, HB, Boshuizen, HC, Peeters, P, Numans, M, Clavel-Chapelon, F, Helen, I, Agapitos, E, Lund, E, Fahey, M, Saracci, R, Kaaks, R & Riboli, E 2003, 'Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)', International Journal of Cancer, vol. 107, no. 4, pp. 629-634. https://doi.org/10.1002/ijc.11426
González, Carlos A. ; Pera, Guillem ; Agudo, Antonio ; Palli, Domenico ; Krogh, Vittorio ; Vineis, Paolo ; Tumino, Rosario ; Panico, Salvatore ; Berglund, Göran ; Simán, Henrik ; Nyrén, Olof ; Agren, Asa ; Martinez, Carmen ; Dorronsoro, Miren ; Barricarte, Aurelio ; Tormo, María J. ; Quiros, Jose R. ; Allen, Naomi ; Bingham, Sheila ; Day, Nicholas ; Miller, Antony ; Nagel, Gabriele ; Boeing, Heiner ; Overvad, Kim ; Tjonneland, Anne ; Bueno-de-Mesquita, H. Bas ; Boshuizen, Hendriek C. ; Peeters, Petra ; Numans, Mattijs ; Clavel-Chapelon, François ; Helen, Ishaki ; Agapitos, Emmanuel ; Lund, Eiliv ; Fahey, Michael ; Saracci, Rodolfo ; Kaaks, Rudolf ; Riboli, Elio. / Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). In: International Journal of Cancer. 2003 ; Vol. 107, No. 4. pp. 629-634.
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AU - González, Carlos A.

AU - Pera, Guillem

AU - Agudo, Antonio

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Vineis, Paolo

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Berglund, Göran

AU - Simán, Henrik

AU - Nyrén, Olof

AU - Agren, Asa

AU - Martinez, Carmen

AU - Dorronsoro, Miren

AU - Barricarte, Aurelio

AU - Tormo, María J.

AU - Quiros, Jose R.

AU - Allen, Naomi

AU - Bingham, Sheila

AU - Day, Nicholas

AU - Miller, Antony

AU - Nagel, Gabriele

AU - Boeing, Heiner

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Bueno-de-Mesquita, H. Bas

AU - Boshuizen, Hendriek C.

AU - Peeters, Petra

AU - Numans, Mattijs

AU - Clavel-Chapelon, François

AU - Helen, Ishaki

AU - Agapitos, Emmanuel

AU - Lund, Eiliv

AU - Fahey, Michael

AU - Saracci, Rodolfo

AU - Kaaks, Rudolf

AU - Riboli, Elio

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