Smoking as an independent determinant of Barrett’s esophagus and, to a lesser degree, of reflux esophagitis

Rosa Filiberti, Vincenzo Fontana, Antonella De Ceglie, Sabrina Blanchi, Enzo Grossi, Domenico Della Casa, Teresa Lacchin, Marina De Matthaeis, Orazio Ignomirelli, Roberta Cappiello, Monica Foti, Francesco Laterza, Vito Annese, Gaetano Iaquinto, Massimo Conio

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the role of smoking in Barrett’s esophagus (BE) and erosive esophagitis (E) compared to endoscopic controls with no BE or E. Smoking is considered a cause of both BE and E, but results on this topic are quite controversial. Methods: Patients with BE (339), E (462) and controls (619: 280 with GERD (gastroesophageal reflux disease)-negative and 339 with GERD-positive anamnesis) were recruited in 12 Italian endoscopy units. Data were obtained from structured questionnaires. Results: Among former smokers, a remarkable upward linear trend was found in BE for all smoking-related predictors. In particular, having smoked for more than 32 years increased the risk more than two times (OR 2.44, 95 % CL 1.33–4.45). When the analysis was performed in the subgroup of subjects with GERD-negative anamnesis, the risk of late quitters (

Original languageEnglish
Pages (from-to)419-429
Number of pages11
JournalCancer Causes and Control
Volume26
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Barrett’s esophagus
  • Esophagitis
  • Gastroesophageal reflux
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Filiberti, R., Fontana, V., De Ceglie, A., Blanchi, S., Grossi, E., Della Casa, D., Lacchin, T., De Matthaeis, M., Ignomirelli, O., Cappiello, R., Foti, M., Laterza, F., Annese, V., Iaquinto, G., & Conio, M. (2015). Smoking as an independent determinant of Barrett’s esophagus and, to a lesser degree, of reflux esophagitis. Cancer Causes and Control, 26(3), 419-429. https://doi.org/10.1007/s10552-014-0518-8