TY - JOUR
T1 - Smoking, DNA adducts and number of risk DNA repair alleles in lung cancer cases, in subjects with benign lung diseases and in controls
AU - Peluso, Marco
AU - Munnia, Armelle
AU - Piro, Sara
AU - Armillis, Alessandra
AU - Ceppi, Marcello
AU - Matullo, Giuseppe
AU - Puntoni, Riccardo
PY - 2010
Y1 - 2010
N2 - Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer cases in respect to 30 subjects with benign lung cancer disease and 40 healthy controls. When the study population was categorized in base to the number of risk alleles, adducts were significantly increased in individuals bearing 3-4 risk alleles (OR=4.1 95% C.I. 1.28-13.09, P=.009). A significant association with smoking was noticed in smokers for more than 40 years carrying 3-4 risk alleles (OR=36.38, 95% C.I. 1.17-1132.84, P=.040). A not statistically significant increment of lung cancer risk was observed in the same group (OR=4.54, 95% C.I. 0.33-62.93, P=.259). Our results suggest that the analysis of the number of risk alleles predicts the interindividual variation in DNA adducts of smokers and lung cancer cases.
AB - Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer cases in respect to 30 subjects with benign lung cancer disease and 40 healthy controls. When the study population was categorized in base to the number of risk alleles, adducts were significantly increased in individuals bearing 3-4 risk alleles (OR=4.1 95% C.I. 1.28-13.09, P=.009). A significant association with smoking was noticed in smokers for more than 40 years carrying 3-4 risk alleles (OR=36.38, 95% C.I. 1.17-1132.84, P=.040). A not statistically significant increment of lung cancer risk was observed in the same group (OR=4.54, 95% C.I. 0.33-62.93, P=.259). Our results suggest that the analysis of the number of risk alleles predicts the interindividual variation in DNA adducts of smokers and lung cancer cases.
UR - http://www.scopus.com/inward/record.url?scp=84863260760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863260760&partnerID=8YFLogxK
U2 - 10.4061/2010/386798
DO - 10.4061/2010/386798
M3 - Article
C2 - 20976253
AN - SCOPUS:84863260760
VL - 2010
JO - Journal of Nucleic Acids
JF - Journal of Nucleic Acids
SN - 2090-0201
M1 - 386798
ER -