Smoking habits and risk of benign breast disease

Fabio Parazzini, Monica Ferraroni, Carlo La Vecchia, John A. Baron, Fabio Levi, Silvia Franceschi, Adriano Decarli

Research output: Contribution to journalArticle

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Abstract

The relationship between smoking habits and the risk of benign breast disease (BBD) was analyzed using data from a case-control study conducted between 1981 and 1983 in the greater Milan area, Northern Italy. Cases (n = 288) were women with histologically confirmed BBD (203 dysplasia, 85 benign tumours) referred to the National Cancer Institute of Milan for biopsies. Controls were women (n = 291) seen on selected days for a cytological smear for cervical cancer in outpatient clinics of the same Institute. No consistent association emerged between various indicators of smoking habits (smoking status, number of cigarettes smoked per day, duration of smoking) and the risk of BBD. Compared with never smokers the relative risk (RR) of all BBD combined was 0.7 (95% confidence interval, Cl: 0.4-1.3) in exsmokers, 1.4 (95% Cl: 0.8-2.5) in smokers of less than 10 cigarettes per day, and 1.1 (95% Cl: 0.7-1.7) in smokers of 10 or more cigarettes per day. There was some suggestion that the risk may be below unity post-menopause, but the relative risks for smokers were not statistically different in pre- (RR = 1.2; 95% Cl: 0.8-1.8) and post-menopausal (RR = 0.6; 95% Cl: 0.2-1.7) women. The risk of benign tumours (chiefly fibradenoma) was higher in current smokers, but this finding was not statistically significant (RR = 1.5; 95% Cl: 0.9-2.6) and the highest risks were observed in the strata of lighter smokers and those with shorter duration of smoking. Overall these results fail to support a negative association between smoking habits and benign breast disease.

Original languageEnglish
Pages (from-to)430-434
Number of pages5
JournalInternational Journal of Epidemiology
Volume20
Issue number2
DOIs
Publication statusPublished - Jun 1991

Fingerprint

Breast Diseases
Smoking
Relative Risk
Habits
Tobacco Products
Tumor
Cancer
Negative Association
Case-control Study
Tumors
Confidence interval
Habit
Postmenopause
Relative risk
National Cancer Institute (U.S.)
Biopsy
Ambulatory Care Facilities
Uterine Cervical Neoplasms
Italy
Case-Control Studies

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Epidemiology

Cite this

Parazzini, F., Ferraroni, M., La Vecchia, C., Baron, J. A., Levi, F., Franceschi, S., & Decarli, A. (1991). Smoking habits and risk of benign breast disease. International Journal of Epidemiology, 20(2), 430-434. https://doi.org/10.1093/ije/20.2.430

Smoking habits and risk of benign breast disease. / Parazzini, Fabio; Ferraroni, Monica; La Vecchia, Carlo; Baron, John A.; Levi, Fabio; Franceschi, Silvia; Decarli, Adriano.

In: International Journal of Epidemiology, Vol. 20, No. 2, 06.1991, p. 430-434.

Research output: Contribution to journalArticle

Parazzini, F, Ferraroni, M, La Vecchia, C, Baron, JA, Levi, F, Franceschi, S & Decarli, A 1991, 'Smoking habits and risk of benign breast disease', International Journal of Epidemiology, vol. 20, no. 2, pp. 430-434. https://doi.org/10.1093/ije/20.2.430
Parazzini F, Ferraroni M, La Vecchia C, Baron JA, Levi F, Franceschi S et al. Smoking habits and risk of benign breast disease. International Journal of Epidemiology. 1991 Jun;20(2):430-434. https://doi.org/10.1093/ije/20.2.430
Parazzini, Fabio ; Ferraroni, Monica ; La Vecchia, Carlo ; Baron, John A. ; Levi, Fabio ; Franceschi, Silvia ; Decarli, Adriano. / Smoking habits and risk of benign breast disease. In: International Journal of Epidemiology. 1991 ; Vol. 20, No. 2. pp. 430-434.
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