Smoking is associated with impaired glucose regulation and a decrease in insulin sensitivity and the disposition index in first-degree relatives of type 2 diabetes subjects independently of the presence of metabolic syndrome

PierMarco M. Piatti, Emanuela Setola, Elena Galluccio, Sabrina Costa, Barbara Fontana, Michela Stuccillo, Valentina Crippa, Alberto Cappelletti, Alberto Margonato, Emanuele Bosi, Lucilla D. Monti

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate glucose tolerance, insulin secretion and insulin resistance according to smoking habits in first-degree relatives of type 2 diabetes patients, a population at high risk for developing diabetes. One thousand three hundred (646 females and 654 males) subjects underwent an oral glucose tolerance test (OGTT) to investigate their glucose metabolism and answered questionnaires about their lifestyle habits. Smoker subjects showed significant impairment compared with non-smoker subjects in 2-h post-oral glucose tolerance test (2hOGTT, 129.3 ± 40.2 vs. 117.7 ± 37.6 mg/dl, p −1 m2, p 

Original languageEnglish
Pages (from-to)793-799
Number of pages7
JournalActa Diabetologica
Volume51
Issue number5
DOIs
Publication statusPublished - Sep 27 2014

Keywords

  • Diabetes mellitus
  • First-degree relatives
  • Glucose tolerance
  • Impaired glucose regulation
  • Insulin resistance
  • Insulin sensitivity
  • Smoking

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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