Smoking is associated with reduced serum levels of the antioxidant enzyme, paraoxonase, in Type 2 diabetic patients

M. Boemi, C. Sirolla, R. Testa, S. Cenerelli, P. Fumelli, R. W. James

Research output: Contribution to journalArticle

Abstract

Aims: To analyse the association of smoking with paraoxonase (PON1) in Type 2 diabetic patients. Methods: Type 2 diabetic patients were recruited independently in two centres (Ancona, Italy and Geneva, Switzerland) and serum PON1 mass and activities were assayed. Current smoking status was established and its association with serum PON1 analysed. Results: Type 2 diabetic patients who smoked had significantly lower serum PON1 mass and activity. This was evident in both groups of patients, even though Swiss patients were composed of coronary patients. Multivariate analyses established that smoking was an independent determinant of serum PON1 status. Conclusions: Smoking is associated with reduced serum levels of the antioxidant enzyme, PON1, even against an already unfavourable background of diabetes and coronary disease. It suggests that a combination of smoking and diabetes may be particularly deleterious for PON1 and consequently for the anti-oxidant capacity of high-density lipoproteins.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalDiabetic Medicine
Volume21
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • HDL
  • Lipoproteins
  • Oxidative stress
  • Risk factor

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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