Smoking-related interstitial lung diseases

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In pulmonary pathology, a wide spectrum of morphological changes is related to the consequences of smoking, and recognizing them on surgical specimens and on small transbronchial biopsies represents a challenge for the pathologist. Respiratory bronchiolitis, also referred to as smoker's bronchiolitis, is a common histologic feature found in the lung tissue of cigarette smokers. When identified as the sole histopathologic finding in the clinical setting of symptomatic interstitial lung disease, a diagnosis of respiratory bronchiolitis-interstitial lung disease is made. Since smoking is recognized to cause a variety of histologic patterns encompassing respiratory bronchiolitis, respiratory bronchiolitisinterstitial lung disease, desquamative interstitial pneumonia and pulmonary Langerhans cell hystiocytosis, smoking-related interstitial lung disease may be a useful concept to keep in mind for the pathologists. The relationship of smoking with each of these entities has been largely established on the basis of epidemiologic evidence. Although they have been retained as distinct and separate conditions in various classifications of interstitial lung diseases, these entities share a number of clinical, radiologic, and pathologic features suggesting that they represent a spectrum of patterns of interstitial lung disease occurring in predisposed individuals who smoke. Evaluation of histologic features, particularly in surgical lung biopsy samples, is important in making the distinction between these disorders. However, even after tissue biopsy, it may sometimes be difficult to clearly separate these entities. Recently, respiratory bronchiolitis-interstitial lung disease with fibrosis has been described and postulated that this is a smoking-related condition distinct from fibrotic non-specific interstitial pneumonia.

Original languageEnglish
Pages (from-to)525-536
Number of pages12
JournalPathologica
Volume102
Issue number6
Publication statusPublished - Dec 2010

Fingerprint

Interstitial Lung Diseases
Bronchiolitis
Smoking
Lung
Biopsy
Langerhans Cells
Smoke
Tobacco Products
Lung Diseases
Fibrosis
Pathology

Keywords

  • Desquamative interstitial pneumonia
  • Langerhans cell histiocytosis
  • Respiratory bronchiolitis
  • Respiratory bronchiolitis interstitial lung diseases

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Smoking-related interstitial lung diseases. / Caminati, A.; Graziano, P.; Sverzellati, N.; Harari, S.

In: Pathologica, Vol. 102, No. 6, 12.2010, p. 525-536.

Research output: Contribution to journalArticle

Caminati, A. ; Graziano, P. ; Sverzellati, N. ; Harari, S. / Smoking-related interstitial lung diseases. In: Pathologica. 2010 ; Vol. 102, No. 6. pp. 525-536.
@article{20a6e5abf8734d7daca85d5b12f1cc99,
title = "Smoking-related interstitial lung diseases",
abstract = "In pulmonary pathology, a wide spectrum of morphological changes is related to the consequences of smoking, and recognizing them on surgical specimens and on small transbronchial biopsies represents a challenge for the pathologist. Respiratory bronchiolitis, also referred to as smoker's bronchiolitis, is a common histologic feature found in the lung tissue of cigarette smokers. When identified as the sole histopathologic finding in the clinical setting of symptomatic interstitial lung disease, a diagnosis of respiratory bronchiolitis-interstitial lung disease is made. Since smoking is recognized to cause a variety of histologic patterns encompassing respiratory bronchiolitis, respiratory bronchiolitisinterstitial lung disease, desquamative interstitial pneumonia and pulmonary Langerhans cell hystiocytosis, smoking-related interstitial lung disease may be a useful concept to keep in mind for the pathologists. The relationship of smoking with each of these entities has been largely established on the basis of epidemiologic evidence. Although they have been retained as distinct and separate conditions in various classifications of interstitial lung diseases, these entities share a number of clinical, radiologic, and pathologic features suggesting that they represent a spectrum of patterns of interstitial lung disease occurring in predisposed individuals who smoke. Evaluation of histologic features, particularly in surgical lung biopsy samples, is important in making the distinction between these disorders. However, even after tissue biopsy, it may sometimes be difficult to clearly separate these entities. Recently, respiratory bronchiolitis-interstitial lung disease with fibrosis has been described and postulated that this is a smoking-related condition distinct from fibrotic non-specific interstitial pneumonia.",
keywords = "Desquamative interstitial pneumonia, Langerhans cell histiocytosis, Respiratory bronchiolitis, Respiratory bronchiolitis interstitial lung diseases",
author = "A. Caminati and P. Graziano and N. Sverzellati and S. Harari",
year = "2010",
month = "12",
language = "English",
volume = "102",
pages = "525--536",
journal = "Pathologica",
issn = "0031-2983",
publisher = "Pacini Editore s.r.l.",
number = "6",

}

TY - JOUR

T1 - Smoking-related interstitial lung diseases

AU - Caminati, A.

AU - Graziano, P.

AU - Sverzellati, N.

AU - Harari, S.

PY - 2010/12

Y1 - 2010/12

N2 - In pulmonary pathology, a wide spectrum of morphological changes is related to the consequences of smoking, and recognizing them on surgical specimens and on small transbronchial biopsies represents a challenge for the pathologist. Respiratory bronchiolitis, also referred to as smoker's bronchiolitis, is a common histologic feature found in the lung tissue of cigarette smokers. When identified as the sole histopathologic finding in the clinical setting of symptomatic interstitial lung disease, a diagnosis of respiratory bronchiolitis-interstitial lung disease is made. Since smoking is recognized to cause a variety of histologic patterns encompassing respiratory bronchiolitis, respiratory bronchiolitisinterstitial lung disease, desquamative interstitial pneumonia and pulmonary Langerhans cell hystiocytosis, smoking-related interstitial lung disease may be a useful concept to keep in mind for the pathologists. The relationship of smoking with each of these entities has been largely established on the basis of epidemiologic evidence. Although they have been retained as distinct and separate conditions in various classifications of interstitial lung diseases, these entities share a number of clinical, radiologic, and pathologic features suggesting that they represent a spectrum of patterns of interstitial lung disease occurring in predisposed individuals who smoke. Evaluation of histologic features, particularly in surgical lung biopsy samples, is important in making the distinction between these disorders. However, even after tissue biopsy, it may sometimes be difficult to clearly separate these entities. Recently, respiratory bronchiolitis-interstitial lung disease with fibrosis has been described and postulated that this is a smoking-related condition distinct from fibrotic non-specific interstitial pneumonia.

AB - In pulmonary pathology, a wide spectrum of morphological changes is related to the consequences of smoking, and recognizing them on surgical specimens and on small transbronchial biopsies represents a challenge for the pathologist. Respiratory bronchiolitis, also referred to as smoker's bronchiolitis, is a common histologic feature found in the lung tissue of cigarette smokers. When identified as the sole histopathologic finding in the clinical setting of symptomatic interstitial lung disease, a diagnosis of respiratory bronchiolitis-interstitial lung disease is made. Since smoking is recognized to cause a variety of histologic patterns encompassing respiratory bronchiolitis, respiratory bronchiolitisinterstitial lung disease, desquamative interstitial pneumonia and pulmonary Langerhans cell hystiocytosis, smoking-related interstitial lung disease may be a useful concept to keep in mind for the pathologists. The relationship of smoking with each of these entities has been largely established on the basis of epidemiologic evidence. Although they have been retained as distinct and separate conditions in various classifications of interstitial lung diseases, these entities share a number of clinical, radiologic, and pathologic features suggesting that they represent a spectrum of patterns of interstitial lung disease occurring in predisposed individuals who smoke. Evaluation of histologic features, particularly in surgical lung biopsy samples, is important in making the distinction between these disorders. However, even after tissue biopsy, it may sometimes be difficult to clearly separate these entities. Recently, respiratory bronchiolitis-interstitial lung disease with fibrosis has been described and postulated that this is a smoking-related condition distinct from fibrotic non-specific interstitial pneumonia.

KW - Desquamative interstitial pneumonia

KW - Langerhans cell histiocytosis

KW - Respiratory bronchiolitis

KW - Respiratory bronchiolitis interstitial lung diseases

UR - http://www.scopus.com/inward/record.url?scp=79953302018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953302018&partnerID=8YFLogxK

M3 - Article

C2 - 21428116

AN - SCOPUS:79953302018

VL - 102

SP - 525

EP - 536

JO - Pathologica

JF - Pathologica

SN - 0031-2983

IS - 6

ER -