Smoking, type of alcoholic beverage and squamous-cell oesophageal cancer in northern Italy

Paola Zambon, Renato Talamini, Carlo La Vecchia, Luigino Dal Maso, Eva Negri, Sandro Tognazzo, Lorenzo Simonato, Silvia Franceschi

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Between 1992 and 1997, we conducted a case-control study of oesophageal cancer in 3 areas of northern Italy. Cases were 275 men, ages 39-77 years (median age 60), with a first incident squamous-cell carcinoma of the oesophagus. Controls were 593 men, ages 36-77 years (median age 60) admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. Number of daily cigarettes was strongly associated with risk [odds ratio (OR) for ≥25 cigarettes/day = 7.0)]. Long- duration smoking showed particularly elevated ORs (OR = 6.4 for ≥35 years), and excess risk declined after smoking cessation (OR = 1.5 after ≥ 10 years). Oesophageal cancer risk steeply rose with increasing level of alcohol consumption. ORs were 6.2 for 35-55 drinks and 24.5 for 84 drinks or more per week. No trend in risk emerged for duration of alcohol drinking or age at start of drinking. The risk in the highest joint level of alcohol drinking and current smoking was increased 130 folds (i.e., compatible with a multiplicative model). Excess risk in drinkers chiefly derived from wine. In conclusion, alcohol drinking and cigarette smoking were both important, but the roles of dose and duration of exposure differed. The association with alcohol was stronger than the one with smoking by exposure intensity, but apparently unaffected by duration or other temporal variables. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalInternational Journal of Cancer
Volume86
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Squamous Cell Neoplasms
Alcoholic Beverages
Esophageal Neoplasms
Italy
Alcohol Drinking
Smoking
Odds Ratio
Tobacco Products
Alcohols
Smoking Cessation
Wine
Esophagus
Drinking
Tobacco
Case-Control Studies
Squamous Cell Carcinoma
Joints

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Smoking, type of alcoholic beverage and squamous-cell oesophageal cancer in northern Italy. / Zambon, Paola; Talamini, Renato; La Vecchia, Carlo; Dal Maso, Luigino; Negri, Eva; Tognazzo, Sandro; Simonato, Lorenzo; Franceschi, Silvia.

In: International Journal of Cancer, Vol. 86, No. 1, 2000, p. 144-149.

Research output: Contribution to journalArticle

Zambon, Paola ; Talamini, Renato ; La Vecchia, Carlo ; Dal Maso, Luigino ; Negri, Eva ; Tognazzo, Sandro ; Simonato, Lorenzo ; Franceschi, Silvia. / Smoking, type of alcoholic beverage and squamous-cell oesophageal cancer in northern Italy. In: International Journal of Cancer. 2000 ; Vol. 86, No. 1. pp. 144-149.
@article{ebc44035258840f5be6c631acdf85f55,
title = "Smoking, type of alcoholic beverage and squamous-cell oesophageal cancer in northern Italy",
abstract = "Between 1992 and 1997, we conducted a case-control study of oesophageal cancer in 3 areas of northern Italy. Cases were 275 men, ages 39-77 years (median age 60), with a first incident squamous-cell carcinoma of the oesophagus. Controls were 593 men, ages 36-77 years (median age 60) admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. Number of daily cigarettes was strongly associated with risk [odds ratio (OR) for ≥25 cigarettes/day = 7.0)]. Long- duration smoking showed particularly elevated ORs (OR = 6.4 for ≥35 years), and excess risk declined after smoking cessation (OR = 1.5 after ≥ 10 years). Oesophageal cancer risk steeply rose with increasing level of alcohol consumption. ORs were 6.2 for 35-55 drinks and 24.5 for 84 drinks or more per week. No trend in risk emerged for duration of alcohol drinking or age at start of drinking. The risk in the highest joint level of alcohol drinking and current smoking was increased 130 folds (i.e., compatible with a multiplicative model). Excess risk in drinkers chiefly derived from wine. In conclusion, alcohol drinking and cigarette smoking were both important, but the roles of dose and duration of exposure differed. The association with alcohol was stronger than the one with smoking by exposure intensity, but apparently unaffected by duration or other temporal variables. (C) 2000 Wiley-Liss, Inc.",
author = "Paola Zambon and Renato Talamini and {La Vecchia}, Carlo and {Dal Maso}, Luigino and Eva Negri and Sandro Tognazzo and Lorenzo Simonato and Silvia Franceschi",
year = "2000",
doi = "10.1002/(SICI)1097-0215(20000401)86:1<144::AID-IJC23>3.0.CO;2-B",
language = "English",
volume = "86",
pages = "144--149",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Smoking, type of alcoholic beverage and squamous-cell oesophageal cancer in northern Italy

AU - Zambon, Paola

AU - Talamini, Renato

AU - La Vecchia, Carlo

AU - Dal Maso, Luigino

AU - Negri, Eva

AU - Tognazzo, Sandro

AU - Simonato, Lorenzo

AU - Franceschi, Silvia

PY - 2000

Y1 - 2000

N2 - Between 1992 and 1997, we conducted a case-control study of oesophageal cancer in 3 areas of northern Italy. Cases were 275 men, ages 39-77 years (median age 60), with a first incident squamous-cell carcinoma of the oesophagus. Controls were 593 men, ages 36-77 years (median age 60) admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. Number of daily cigarettes was strongly associated with risk [odds ratio (OR) for ≥25 cigarettes/day = 7.0)]. Long- duration smoking showed particularly elevated ORs (OR = 6.4 for ≥35 years), and excess risk declined after smoking cessation (OR = 1.5 after ≥ 10 years). Oesophageal cancer risk steeply rose with increasing level of alcohol consumption. ORs were 6.2 for 35-55 drinks and 24.5 for 84 drinks or more per week. No trend in risk emerged for duration of alcohol drinking or age at start of drinking. The risk in the highest joint level of alcohol drinking and current smoking was increased 130 folds (i.e., compatible with a multiplicative model). Excess risk in drinkers chiefly derived from wine. In conclusion, alcohol drinking and cigarette smoking were both important, but the roles of dose and duration of exposure differed. The association with alcohol was stronger than the one with smoking by exposure intensity, but apparently unaffected by duration or other temporal variables. (C) 2000 Wiley-Liss, Inc.

AB - Between 1992 and 1997, we conducted a case-control study of oesophageal cancer in 3 areas of northern Italy. Cases were 275 men, ages 39-77 years (median age 60), with a first incident squamous-cell carcinoma of the oesophagus. Controls were 593 men, ages 36-77 years (median age 60) admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. Number of daily cigarettes was strongly associated with risk [odds ratio (OR) for ≥25 cigarettes/day = 7.0)]. Long- duration smoking showed particularly elevated ORs (OR = 6.4 for ≥35 years), and excess risk declined after smoking cessation (OR = 1.5 after ≥ 10 years). Oesophageal cancer risk steeply rose with increasing level of alcohol consumption. ORs were 6.2 for 35-55 drinks and 24.5 for 84 drinks or more per week. No trend in risk emerged for duration of alcohol drinking or age at start of drinking. The risk in the highest joint level of alcohol drinking and current smoking was increased 130 folds (i.e., compatible with a multiplicative model). Excess risk in drinkers chiefly derived from wine. In conclusion, alcohol drinking and cigarette smoking were both important, but the roles of dose and duration of exposure differed. The association with alcohol was stronger than the one with smoking by exposure intensity, but apparently unaffected by duration or other temporal variables. (C) 2000 Wiley-Liss, Inc.

UR - http://www.scopus.com/inward/record.url?scp=0034090915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034090915&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0215(20000401)86:1<144::AID-IJC23>3.0.CO;2-B

DO - 10.1002/(SICI)1097-0215(20000401)86:1<144::AID-IJC23>3.0.CO;2-B

M3 - Article

VL - 86

SP - 144

EP - 149

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 1

ER -