Smoldering multiple myeloma

the role of different scoring systems in identifying high-risk patients in real-life practice

Federica Cocito, Silvia Mangiacavalli, Virginia Valeria Ferretti, Claudio Salvatore Cartia, Maya Ganzetti, Pietro Benveuti, Alessandra Pompa, Martina Catalano, Elena Fugazza, Benedetta Landini, Luca Arcaini, Alessandro Corso

Research output: Contribution to journalArticle

Abstract

We explore the predictive role of 2014-updated International Myeloma Working Group (IMWG) diagnostic criteria and of some of currently available risk models for progression to symptomatic myeloma when applied in our unselected population of 75 smoldering multiple myeloma (SMM) patients observed between 2000 and 2015. Risk scores including routinely used clinical parameters such as bone marrow plasmacell infiltration rate, immunoparesis, serum monoclonal component (sMC) value, and altered free light chain ratio (FLCr), were clinically useful to identify SMM patients at higher risk of progression. Time to myeloma progression in our ultra-high risk SMM according to IMWG diagnostic update criteria was very short (12.4 months). Our analysis identified as independent reliable predictors of progression altered FLCr as well as increasing plasma cell infiltration which are part of most commonly applied risk models. Waiting for new scoring systems, bone marrow evaluation and complete laboratory screening are still milestones for SMM management.

Original languageEnglish
JournalLeukemia and Lymphoma
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Multiple Myeloma
Bone Marrow
Light
Plasma Cells
Serum
Population

Keywords

  • bone marrow plasma cells
  • free light chains
  • scoring systems
  • Smoldering myeloma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Smoldering multiple myeloma : the role of different scoring systems in identifying high-risk patients in real-life practice. / Cocito, Federica; Mangiacavalli, Silvia; Valeria Ferretti, Virginia; Cartia, Claudio Salvatore; Ganzetti, Maya; Benveuti, Pietro; Pompa, Alessandra; Catalano, Martina; Fugazza, Elena; Landini, Benedetta; Arcaini, Luca; Corso, Alessandro.

In: Leukemia and Lymphoma, 01.01.2019.

Research output: Contribution to journalArticle

@article{94c47aaaa78b4ae7b95585fc0a4c364f,
title = "Smoldering multiple myeloma: the role of different scoring systems in identifying high-risk patients in real-life practice",
abstract = "We explore the predictive role of 2014-updated International Myeloma Working Group (IMWG) diagnostic criteria and of some of currently available risk models for progression to symptomatic myeloma when applied in our unselected population of 75 smoldering multiple myeloma (SMM) patients observed between 2000 and 2015. Risk scores including routinely used clinical parameters such as bone marrow plasmacell infiltration rate, immunoparesis, serum monoclonal component (sMC) value, and altered free light chain ratio (FLCr), were clinically useful to identify SMM patients at higher risk of progression. Time to myeloma progression in our ultra-high risk SMM according to IMWG diagnostic update criteria was very short (12.4 months). Our analysis identified as independent reliable predictors of progression altered FLCr as well as increasing plasma cell infiltration which are part of most commonly applied risk models. Waiting for new scoring systems, bone marrow evaluation and complete laboratory screening are still milestones for SMM management.",
keywords = "bone marrow plasma cells, free light chains, scoring systems, Smoldering myeloma",
author = "Federica Cocito and Silvia Mangiacavalli and {Valeria Ferretti}, Virginia and Cartia, {Claudio Salvatore} and Maya Ganzetti and Pietro Benveuti and Alessandra Pompa and Martina Catalano and Elena Fugazza and Benedetta Landini and Luca Arcaini and Alessandro Corso",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/10428194.2019.1620948",
language = "English",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Smoldering multiple myeloma

T2 - the role of different scoring systems in identifying high-risk patients in real-life practice

AU - Cocito, Federica

AU - Mangiacavalli, Silvia

AU - Valeria Ferretti, Virginia

AU - Cartia, Claudio Salvatore

AU - Ganzetti, Maya

AU - Benveuti, Pietro

AU - Pompa, Alessandra

AU - Catalano, Martina

AU - Fugazza, Elena

AU - Landini, Benedetta

AU - Arcaini, Luca

AU - Corso, Alessandro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We explore the predictive role of 2014-updated International Myeloma Working Group (IMWG) diagnostic criteria and of some of currently available risk models for progression to symptomatic myeloma when applied in our unselected population of 75 smoldering multiple myeloma (SMM) patients observed between 2000 and 2015. Risk scores including routinely used clinical parameters such as bone marrow plasmacell infiltration rate, immunoparesis, serum monoclonal component (sMC) value, and altered free light chain ratio (FLCr), were clinically useful to identify SMM patients at higher risk of progression. Time to myeloma progression in our ultra-high risk SMM according to IMWG diagnostic update criteria was very short (12.4 months). Our analysis identified as independent reliable predictors of progression altered FLCr as well as increasing plasma cell infiltration which are part of most commonly applied risk models. Waiting for new scoring systems, bone marrow evaluation and complete laboratory screening are still milestones for SMM management.

AB - We explore the predictive role of 2014-updated International Myeloma Working Group (IMWG) diagnostic criteria and of some of currently available risk models for progression to symptomatic myeloma when applied in our unselected population of 75 smoldering multiple myeloma (SMM) patients observed between 2000 and 2015. Risk scores including routinely used clinical parameters such as bone marrow plasmacell infiltration rate, immunoparesis, serum monoclonal component (sMC) value, and altered free light chain ratio (FLCr), were clinically useful to identify SMM patients at higher risk of progression. Time to myeloma progression in our ultra-high risk SMM according to IMWG diagnostic update criteria was very short (12.4 months). Our analysis identified as independent reliable predictors of progression altered FLCr as well as increasing plasma cell infiltration which are part of most commonly applied risk models. Waiting for new scoring systems, bone marrow evaluation and complete laboratory screening are still milestones for SMM management.

KW - bone marrow plasma cells

KW - free light chains

KW - scoring systems

KW - Smoldering myeloma

UR - http://www.scopus.com/inward/record.url?scp=85067614234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067614234&partnerID=8YFLogxK

U2 - 10.1080/10428194.2019.1620948

DO - 10.1080/10428194.2019.1620948

M3 - Article

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

ER -