SNAP-25 in neuropsychiatric disorders

Irene Corradini, Claudia Verderio, Mariaelvina Sala, Michael C. Wilson, Michela Matteoli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

68 Citations (Scopus)

Abstract

SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages93-99
Number of pages7
Volume1152
DOIs
Publication statusPublished - Jan 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1152
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Synaptosomal-Associated Protein 25
SNARE Proteins
R-SNARE Proteins
Qa-SNARE Proteins
Synaptic Vesicles
Exocytosis
Medical Genetics
Calcium Channels
Cell membranes
Nervous System Diseases
Neurotransmitter Agents
Blood Proteins
Membrane Proteins
Proteins
Genes
Cell Membrane
Gene Expression
Electric potential
Population

Keywords

  • ADHD
  • Calcium channels
  • Epilepsy
  • Schizophrenia
  • SNAP-25

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Corradini, I., Verderio, C., Sala, M., Wilson, M. C., & Matteoli, M. (2009). SNAP-25 in neuropsychiatric disorders. In Annals of the New York Academy of Sciences (Vol. 1152, pp. 93-99). (Annals of the New York Academy of Sciences; Vol. 1152). https://doi.org/10.1111/j.1749-6632.2008.03995.x

SNAP-25 in neuropsychiatric disorders. / Corradini, Irene; Verderio, Claudia; Sala, Mariaelvina; Wilson, Michael C.; Matteoli, Michela.

Annals of the New York Academy of Sciences. Vol. 1152 2009. p. 93-99 (Annals of the New York Academy of Sciences; Vol. 1152).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Corradini, I, Verderio, C, Sala, M, Wilson, MC & Matteoli, M 2009, SNAP-25 in neuropsychiatric disorders. in Annals of the New York Academy of Sciences. vol. 1152, Annals of the New York Academy of Sciences, vol. 1152, pp. 93-99. https://doi.org/10.1111/j.1749-6632.2008.03995.x
Corradini I, Verderio C, Sala M, Wilson MC, Matteoli M. SNAP-25 in neuropsychiatric disorders. In Annals of the New York Academy of Sciences. Vol. 1152. 2009. p. 93-99. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2008.03995.x
Corradini, Irene ; Verderio, Claudia ; Sala, Mariaelvina ; Wilson, Michael C. ; Matteoli, Michela. / SNAP-25 in neuropsychiatric disorders. Annals of the New York Academy of Sciences. Vol. 1152 2009. pp. 93-99 (Annals of the New York Academy of Sciences).
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