SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders

Franca R. Guerini, Elisabetta Bolognesi, Matteo Chiappedi, Salvatorica Manca, Alessandro Ghezzo, Cristina Agliardi, Stefano Sotgiu, Sonia Usai, Michela Matteoli, Mario Clerici

Research output: Contribution to journalArticle

Abstract

Synaptosomal-associated protein of 25 kD (SNAP-25), a protein participating in the regulation of synaptic vesicle exocytosis and in calcium homeostasis, was recently involved in neuropsychiatric conditions. Because alterations affecting the homeostasis of calcium are described in patients affected by autism spectrum disorders (ASD) we investigated a possible involvement of SNAP-25 in ASD by evaluating five SNAP-25 gene polymorphisms in a cohort of 67 ASD children. Data analyzed in relationship with clinical outcomes and compared to those of 205 healthy sex-matched children did not reveal significant differences. Further analyses nevertheless showed the presence of highly significant associations of the rs363043 (CT) genotype, localized in the intron 1 region that affects the transcription factor binding sites of the SNAP-25 gene, with both increasing CARS (p = 0.001) and hyperactivity scores (p = 0.006). The finding that polymorphisms of the SNAP-25 gene, a gene involved in neurotransmission and regulation of calcium homeostasis, are associated with the degree of hyperactivity in children with ASD, reinforces the hypothesis that alterations of these mechanisms play a pivotal role in the events leading to ASD-associated behavioral impairment. Modulation of these processes could result in novel therapeutic strategies.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalPharmacological Research
Volume64
Issue number3
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Autism spectrum disorders
  • Calcium
  • Hyperactivity
  • Single nucleotide polymorphism
  • SNAP-25

ASJC Scopus subject areas

  • Pharmacology

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