SnCl2/RSH: A versatile catalytic system for the synthesis of 4-Alkylsulfanyl-indazole derivatives

Assoman Kouakou, Hakima Chicha, El Mostapha Rakib, Ahmed Gamouh, Abdellah Hannioui, Mohammed Chigr, Maurizio Viale

Research output: Contribution to journalArticle

Abstract

The treatment of alkylated nitro derivatives of indazole with stannous chloride in alkanethiol gave after coupling of the obtained amines with 4-methoxybenzenesulfonyl chloride in pyridine the new N-(4-Alkylsulfanylindazol-7-yl)-4-methoxybenzene sulfonamides via the nucleophilic substitution of hydrogen in position 4 of indazole, together with the expected 4-methoxy-N-(indazol-7-yl)-benzenesulfonamides. All the newly synthesized compounds have been characterized by elemental analysis and spectroscopic data.

Original languageEnglish
Pages (from-to)86-95
Number of pages10
JournalJournal of Sulfur Chemistry
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 2 2015

Keywords

  • alkanethiol
  • N-(4-Alkyl sulfanylindazol-7-yl)arylsulfonamide
  • N-Alkyl-7-nitroindazole
  • reduction
  • stannous chloride

ASJC Scopus subject areas

  • Chemistry(all)

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