Social adjustment could be associated with the serotonin transporter gene in remitted patients with mood disorders and healthy subjects

Alessandro Serretti, Laura Mandelli, Cristina Lorenzi, Enrico Smeraldi

Research output: Contribution to journalArticle


We investigated the serotonin transporter gene (5-HTTLPR) in the functioning of euthymic patients with mood disorders (n = 285) and healthy controls (n = 94). The 5-HTTLPR genotype showed marginal associations with working, familial and social adjustment, with marked differences between controls and patients. Because of the exploratory nature of our analyses, all results should be viewed with caution. However, we observed how the s/s variant, commonly associated with detrimental effects, could be beneficial in specific areas of social adjustment.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalPsychiatry Research
Issue number2
Publication statusPublished - Apr 15 2005



  • Behavior
  • Depressive disorder
  • Evolution
  • Selection
  • Serotonin
  • Social function

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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