Social adversity and epigenetic aging

A multi-cohort study on socioeconomic differences in peripheral blood DNA methylation

Giovanni Fiorito, Silvia Polidoro, Pierre Antoine Dugué, Mika Kivimaki, Erica Ponzi, Giuseppe Matullo, Simonetta Guarrera, Manuela B. Assumma, Panagiotis Georgiadis, Soterios A. Kyrtopoulos, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Marc Chadeau-Hyam, Silvia Stringhini, Gianluca Severi, Allison M. Hodge, Graham G. Giles & 10 others Riccardo Marioni, Richard Karlsson Linnér, Aisling M. O'Halloran, Rose A. Kenny, Richard Layte, Laura Baglietto, Oliver Robinson, Cathal McCrory, Roger L. Milne, Paolo Vineis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.

Original languageEnglish
Article number16266
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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DNA Methylation
Epigenomics
Social Class
Cohort Studies
Social Environment
Life Expectancy
Age of Onset
Ireland
Italy
Habits
Life Style

ASJC Scopus subject areas

  • General

Cite this

Social adversity and epigenetic aging : A multi-cohort study on socioeconomic differences in peripheral blood DNA methylation. / Fiorito, Giovanni; Polidoro, Silvia; Dugué, Pierre Antoine; Kivimaki, Mika; Ponzi, Erica; Matullo, Giuseppe; Guarrera, Simonetta; Assumma, Manuela B.; Georgiadis, Panagiotis; Kyrtopoulos, Soterios A.; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Chadeau-Hyam, Marc; Stringhini, Silvia; Severi, Gianluca; Hodge, Allison M.; Giles, Graham G.; Marioni, Riccardo; Karlsson Linnér, Richard; O'Halloran, Aisling M.; Kenny, Rose A.; Layte, Richard; Baglietto, Laura; Robinson, Oliver; McCrory, Cathal; Milne, Roger L.; Vineis, Paolo.

In: Scientific Reports, Vol. 7, No. 1, 16266, 01.12.2017.

Research output: Contribution to journalArticle

Fiorito, G, Polidoro, S, Dugué, PA, Kivimaki, M, Ponzi, E, Matullo, G, Guarrera, S, Assumma, MB, Georgiadis, P, Kyrtopoulos, SA, Krogh, V, Palli, D, Panico, S, Sacerdote, C, Tumino, R, Chadeau-Hyam, M, Stringhini, S, Severi, G, Hodge, AM, Giles, GG, Marioni, R, Karlsson Linnér, R, O'Halloran, AM, Kenny, RA, Layte, R, Baglietto, L, Robinson, O, McCrory, C, Milne, RL & Vineis, P 2017, 'Social adversity and epigenetic aging: A multi-cohort study on socioeconomic differences in peripheral blood DNA methylation', Scientific Reports, vol. 7, no. 1, 16266. https://doi.org/10.1038/s41598-017-16391-5
Fiorito, Giovanni ; Polidoro, Silvia ; Dugué, Pierre Antoine ; Kivimaki, Mika ; Ponzi, Erica ; Matullo, Giuseppe ; Guarrera, Simonetta ; Assumma, Manuela B. ; Georgiadis, Panagiotis ; Kyrtopoulos, Soterios A. ; Krogh, Vittorio ; Palli, Domenico ; Panico, Salvatore ; Sacerdote, Carlotta ; Tumino, Rosario ; Chadeau-Hyam, Marc ; Stringhini, Silvia ; Severi, Gianluca ; Hodge, Allison M. ; Giles, Graham G. ; Marioni, Riccardo ; Karlsson Linnér, Richard ; O'Halloran, Aisling M. ; Kenny, Rose A. ; Layte, Richard ; Baglietto, Laura ; Robinson, Oliver ; McCrory, Cathal ; Milne, Roger L. ; Vineis, Paolo. / Social adversity and epigenetic aging : A multi-cohort study on socioeconomic differences in peripheral blood DNA methylation. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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