TY - JOUR
T1 - Social Cognition in a Research Domain Criteria Perspective
T2 - A Bridge Between Schizophrenia and Autism Spectra Disorders
AU - Barlati, Stefano
AU - Minelli, Alessandra
AU - Ceraso, Anna
AU - Nibbio, Gabriele
AU - Carvalho Silva, Rosana
AU - Deste, Giacomo
AU - Turrina, Cesare
AU - Vita, Antonio
N1 - Publisher Copyright:
© Copyright © 2020 Barlati, Minelli, Ceraso, Nibbio, Carvalho Silva, Deste, Turrina and Vita.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8/28
Y1 - 2020/8/28
N2 - Schizophrenia and autism spectra disorders are currently conceptualized as distinct clinical categories. However, the relationship between these two nosological entities has been revisited in recent years due to the evidence that they share some important clinical and neurobiological features, putting into question the nature and the extent of their commonalities and differences. In this respect, some core symptoms that are present in both disorders, such as social cognitive deficits, could be a primary target of investigation. This review briefly summarizes the commonalities and overlapping features between schizophrenia and autism spectra disorders in social cognitive functions, considering this construct in a Research Domain Criteria perspective. The clinical manifestation of deficits in social cognition are similar in schizophrenia spectrum disorders and autism spectrum disorders, and brain areas that appear to be altered in relation to these impairments are largely shared; however, the results of various studies suggest that, in some cases, the qualitative nature of these alterations may be different in the two spectra. Moreover, relevant differences could be present at the level of brain networks and connections. More research is required in this field, regarding molecular and genetic aspects of both spectra, to better define the neurobiological mechanisms involved in social cognition deficits, with the objective of developing specific and targeted treatments.
AB - Schizophrenia and autism spectra disorders are currently conceptualized as distinct clinical categories. However, the relationship between these two nosological entities has been revisited in recent years due to the evidence that they share some important clinical and neurobiological features, putting into question the nature and the extent of their commonalities and differences. In this respect, some core symptoms that are present in both disorders, such as social cognitive deficits, could be a primary target of investigation. This review briefly summarizes the commonalities and overlapping features between schizophrenia and autism spectra disorders in social cognitive functions, considering this construct in a Research Domain Criteria perspective. The clinical manifestation of deficits in social cognition are similar in schizophrenia spectrum disorders and autism spectrum disorders, and brain areas that appear to be altered in relation to these impairments are largely shared; however, the results of various studies suggest that, in some cases, the qualitative nature of these alterations may be different in the two spectra. Moreover, relevant differences could be present at the level of brain networks and connections. More research is required in this field, regarding molecular and genetic aspects of both spectra, to better define the neurobiological mechanisms involved in social cognition deficits, with the objective of developing specific and targeted treatments.
KW - autism spectrum disorder
KW - genetic
KW - neurodevelopmental disorders
KW - research domain criteria (RDoC) neuroimaging
KW - schizophrenia spectrum disorder
KW - social cognition
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U2 - 10.3389/fpsyt.2020.00806
DO - 10.3389/fpsyt.2020.00806
M3 - Review article
AN - SCOPUS:85090793487
VL - 11
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
SN - 1664-0640
M1 - 806
ER -