Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research: Part i - Analytical validation and clinical qualification

Valentina O. Puntmann, Silvia Valbuena, Rocio Hinojar, Steffen E. Petersen, John P. Greenwood, Christopher M. Kramer, Raymond Y. Kwong, Gerry P. McCann, Colin Berry, Eike Nagel, David Bluemke, Jens Bremerich, Rene Botnar, Chiara Bucciarelli-Ducci, Robin P. Choudhury, Marc Dweck, Ingo Eitel, Vic Ferrari, Matthias Friedrich, Greg HundleyMassimo Lombardi, Teresa Lopez Fernandez, Thomas Marwick, Jagat Narula, Stefan Neubauer, Amit Patel, Dudley Pennell, Sven Plein, Sanjay Prasad, Frank Rademakers, Subha Raman, Hajime Sakuma, Javier Sanz, Jeannette Schulz-Menger, Orlando Simonetti, Andrew Swift, Andrew J. Taylor, T. Teixeira, Holger Thiele, Martin Ugander, Jos J. Westenberg, Alistair A. Young

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Cardiovascular disease remains a leading cause of morbidity and mortality globally. Changing natural history of the disease due to improved care of acute conditions and ageing population necessitates new strategies to tackle conditions which have more chronic and indolent course. These include an increased deployment of safe screening methods, life-long surveillance, and monitoring of both disease activity and tailored-treatment, by way of increasingly personalized medical care. Cardiovascular magnetic resonance (CMR) is a non-invasive, ionising radiation-free method, which can support a significant number of clinically relevant measurements and offers new opportunities to advance the state of art of diagnosis, prognosis and treatment. The objective of the SCMR Clinical Trial Taskforce was to summarizes the evidence to emphasize where currently CMR-guided clinical care can indeed translate into meaningful use and efficient deployment of resources results in meaningful and efficient use. The objective of the present initiative was to provide an appraisal of evidence on analytical validation, including the accuracy and precision, and clinical qualification of parameters in disease context, clarifying the strengths and weaknesses of the state of art, as well as the gaps in the current evidence This paper is complementary to the existing position papers on standardized acquisition and post-processing ensuring robustness and transferability for widespread use. Themed imaging-endpoint guidance on trial design to support drug-discovery or change in clinical practice (part II), will be presented in a follow-up paper in due course. As CMR continues to undergo rapid development, regular updates of the present recommendations are foreseen.

Original languageEnglish
Article number67
JournalJournal of Cardiovascular Magnetic Resonance
Volume20
Issue number1
DOIs
Publication statusPublished - Sep 20 2018

Fingerprint

Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Research
Nonionizing Radiation
Drug Discovery
Cardiovascular Diseases
Clinical Trials
Morbidity
Mortality
Population

Keywords

  • Biomarker
  • Cardiac magnetic resonance
  • Imaging
  • Position paper
  • SCMR

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research : Part i - Analytical validation and clinical qualification. / Puntmann, Valentina O.; Valbuena, Silvia; Hinojar, Rocio; Petersen, Steffen E.; Greenwood, John P.; Kramer, Christopher M.; Kwong, Raymond Y.; McCann, Gerry P.; Berry, Colin; Nagel, Eike; Bluemke, David; Bremerich, Jens; Botnar, Rene; Bucciarelli-Ducci, Chiara; Choudhury, Robin P.; Dweck, Marc; Eitel, Ingo; Ferrari, Vic; Friedrich, Matthias; Hundley, Greg; Lombardi, Massimo; Lopez Fernandez, Teresa; Marwick, Thomas; Narula, Jagat; Neubauer, Stefan; Patel, Amit; Pennell, Dudley; Plein, Sven; Prasad, Sanjay; Rademakers, Frank; Raman, Subha; Sakuma, Hajime; Sanz, Javier; Schulz-Menger, Jeannette; Simonetti, Orlando; Swift, Andrew; Taylor, Andrew J.; Teixeira, T.; Thiele, Holger; Ugander, Martin; Westenberg, Jos J.; Young, Alistair A.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 20, No. 1, 67, 20.09.2018.

Research output: Contribution to journalReview article

Puntmann, VO, Valbuena, S, Hinojar, R, Petersen, SE, Greenwood, JP, Kramer, CM, Kwong, RY, McCann, GP, Berry, C, Nagel, E, Bluemke, D, Bremerich, J, Botnar, R, Bucciarelli-Ducci, C, Choudhury, RP, Dweck, M, Eitel, I, Ferrari, V, Friedrich, M, Hundley, G, Lombardi, M, Lopez Fernandez, T, Marwick, T, Narula, J, Neubauer, S, Patel, A, Pennell, D, Plein, S, Prasad, S, Rademakers, F, Raman, S, Sakuma, H, Sanz, J, Schulz-Menger, J, Simonetti, O, Swift, A, Taylor, AJ, Teixeira, T, Thiele, H, Ugander, M, Westenberg, JJ & Young, AA 2018, 'Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research: Part i - Analytical validation and clinical qualification', Journal of Cardiovascular Magnetic Resonance, vol. 20, no. 1, 67. https://doi.org/10.1186/s12968-018-0484-5
Puntmann, Valentina O. ; Valbuena, Silvia ; Hinojar, Rocio ; Petersen, Steffen E. ; Greenwood, John P. ; Kramer, Christopher M. ; Kwong, Raymond Y. ; McCann, Gerry P. ; Berry, Colin ; Nagel, Eike ; Bluemke, David ; Bremerich, Jens ; Botnar, Rene ; Bucciarelli-Ducci, Chiara ; Choudhury, Robin P. ; Dweck, Marc ; Eitel, Ingo ; Ferrari, Vic ; Friedrich, Matthias ; Hundley, Greg ; Lombardi, Massimo ; Lopez Fernandez, Teresa ; Marwick, Thomas ; Narula, Jagat ; Neubauer, Stefan ; Patel, Amit ; Pennell, Dudley ; Plein, Sven ; Prasad, Sanjay ; Rademakers, Frank ; Raman, Subha ; Sakuma, Hajime ; Sanz, Javier ; Schulz-Menger, Jeannette ; Simonetti, Orlando ; Swift, Andrew ; Taylor, Andrew J. ; Teixeira, T. ; Thiele, Holger ; Ugander, Martin ; Westenberg, Jos J. ; Young, Alistair A. / Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research : Part i - Analytical validation and clinical qualification. In: Journal of Cardiovascular Magnetic Resonance. 2018 ; Vol. 20, No. 1.
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AU - Lombardi, Massimo

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AU - Swift, Andrew

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AU - Teixeira, T.

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