Sociodemographic and treatment related variables are poor predictors of haloperidol induced motor side effects

Ina Giegling, Antonio Drago, Martin Schäfer, Hans Jürgen Möller, Dan Rujescu, Alessandro Serretti

Research output: Contribution to journalArticle

Abstract

Age, haloperidol plasma levels and sex are associated with haloperidol induced motor side effects according to some lines of evidence, even though some conflicting findings mandate further research. We here report that age and sex were associated with dystonia during the early phases of treatment (p = 0.0006 and p = 0.008 respectively), but are overall poor predictors of the Extrapyramidal Symptom Rating Scale scores' variation over time (first month of treatment) in a sample of 60 acutely ill haloperidol treated psychotic patients. We conclude that age, sex and haloperidol plasma levels are not robust predictors of haloperidol induced motor side effects. Nonetheless, some limits of the study including the small sample size and the imputation of missing data could have diminished the power of detecting minor impacts of the investigated clinical predictors of the haloperidol induced motor side effects.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 15 2011

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Keywords

  • Haloperidol
  • Motor side effects
  • Predictors

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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