Sodium-dependent, high-affinity taurine transport into rat brain synaptosomes

B. A. Meiners, R. C. Speth, N. Bresolin, R. J. Huxtable, H. I. Yamamura

Research output: Contribution to journalArticle

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Abstract

Taurine uptake into rat brain synaptosomal fractions appears to occur by two saturable transport processes and by bulk diffusion. The transport requires the presence of sodium ions. The dependence of the transport on temperature and cellular respiration implies that the uptake is an active process. The active process is specific for taurine and closely related amino acids. Brain regions differ in their ability to transport taurine. Uptake is not due to mitochondrial contamination of the synaptosomal fractions. However, glial contamination might partly contribute to the uptake. Kainic acid lesions of rat corpus striatum and cerebellum reduce taurine uptake implying that the uptake is, at least partly, into neurons.

Original languageEnglish
Pages (from-to)2695-2700
Number of pages6
JournalFederation Proceedings
Volume39
Issue number9
Publication statusPublished - 1980

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Synaptosomes
Taurine
Sodium
Brain
Cell Respiration
Corpus Striatum
Kainic Acid
Neuroglia
Cerebellum
Ions
Neurons
Amino Acids
Temperature

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Meiners, B. A., Speth, R. C., Bresolin, N., Huxtable, R. J., & Yamamura, H. I. (1980). Sodium-dependent, high-affinity taurine transport into rat brain synaptosomes. Federation Proceedings, 39(9), 2695-2700.

Sodium-dependent, high-affinity taurine transport into rat brain synaptosomes. / Meiners, B. A.; Speth, R. C.; Bresolin, N.; Huxtable, R. J.; Yamamura, H. I.

In: Federation Proceedings, Vol. 39, No. 9, 1980, p. 2695-2700.

Research output: Contribution to journalArticle

Meiners, BA, Speth, RC, Bresolin, N, Huxtable, RJ & Yamamura, HI 1980, 'Sodium-dependent, high-affinity taurine transport into rat brain synaptosomes', Federation Proceedings, vol. 39, no. 9, pp. 2695-2700.
Meiners, B. A. ; Speth, R. C. ; Bresolin, N. ; Huxtable, R. J. ; Yamamura, H. I. / Sodium-dependent, high-affinity taurine transport into rat brain synaptosomes. In: Federation Proceedings. 1980 ; Vol. 39, No. 9. pp. 2695-2700.
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