Sodium-dependent interaction of benzamides with dopamine receptors

E. Stefanini, A. M. Marchisio, P. Devoto, F. Vernaleone, R. Collu, P. F. Spano

Research output: Contribution to journalArticlepeer-review


Sulpiride and other benzamide (BM)-displacing activity on[3H]-spiroperidol ([3H]SPIR) binding by rat striatal dopaminergic receptors was found to be uniquely sodium-dependent, while classical neuroleptic (NL) activity was not influenced by NaCl. These results suggest the existence of at least two populations of striatal dopaminergic receptors, sodium-dependent and sodium-independent, through which BM and NL respectively interact.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalBrain Research
Issue number1
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Neuroscience(all)


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