Sodium-dependent interaction of benzamides with dopamine receptors

E. Stefanini, A. M. Marchisio, P. Devoto, F. Vernaleone, R. Collu, P. F. Spano

Research output: Contribution to journalArticle

Abstract

Sulpiride and other benzamide (BM)-displacing activity on[3H]-spiroperidol ([3H]SPIR) binding by rat striatal dopaminergic receptors was found to be uniquely sodium-dependent, while classical neuroleptic (NL) activity was not influenced by NaCl. These results suggest the existence of at least two populations of striatal dopaminergic receptors, sodium-dependent and sodium-independent, through which BM and NL respectively interact.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalBrain Research
Volume198
Issue number1
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Stefanini, E., Marchisio, A. M., Devoto, P., Vernaleone, F., Collu, R., & Spano, P. F. (1980). Sodium-dependent interaction of benzamides with dopamine receptors. Brain Research, 198(1), 229-233. https://doi.org/10.1016/0006-8993(80)90360-1