Sodium fusidate in Gillain-Barre syndrome: A case report

F. Nicoletti, A. Nicoletti, S. Giuffrida, R. Di Marco, P. L. Meroni, K. Bendtzen, M. Lunetta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A patient with Guillain-Barre syndrome is reported on who responded favourably to a short course treatment with the novel immunosuppressant sodium fusidate (Fucidin), given at a daily dose of 1.5 g for one week. Along with prompt and clear cut clinical improvement, treatment with Fucidin was associated with a rapid decline in the blood concentrations of inflammatory cytokines presumably implicated in the pathogenesis of Guillain-Barre syndrome such as interleukin-2, interferon-γ, and tumor necrosis factor-α. The ex vivo production of these cytokines was also markedly diminished compared with pretreatment values. Fucidin was well tolerated and no clinical or biochemical side effects were seen.

Original languageEnglish
Pages (from-to)266-268
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume65
Issue number2
Publication statusPublished - 1998

Fingerprint

Fusidic Acid
Guillain-Barre Syndrome
Cytokines
Immunosuppressive Agents
Interferons
Interleukin-2
Tumor Necrosis Factor-alpha
Therapeutics

Keywords

  • Autoimmunity
  • Cytokines
  • Fucidin
  • Guillian-Barre syndrome

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Nicoletti, F., Nicoletti, A., Giuffrida, S., Di Marco, R., Meroni, P. L., Bendtzen, K., & Lunetta, M. (1998). Sodium fusidate in Gillain-Barre syndrome: A case report. Journal of Neurology, Neurosurgery and Psychiatry, 65(2), 266-268.

Sodium fusidate in Gillain-Barre syndrome : A case report. / Nicoletti, F.; Nicoletti, A.; Giuffrida, S.; Di Marco, R.; Meroni, P. L.; Bendtzen, K.; Lunetta, M.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 65, No. 2, 1998, p. 266-268.

Research output: Contribution to journalArticle

Nicoletti, F, Nicoletti, A, Giuffrida, S, Di Marco, R, Meroni, PL, Bendtzen, K & Lunetta, M 1998, 'Sodium fusidate in Gillain-Barre syndrome: A case report', Journal of Neurology, Neurosurgery and Psychiatry, vol. 65, no. 2, pp. 266-268.
Nicoletti F, Nicoletti A, Giuffrida S, Di Marco R, Meroni PL, Bendtzen K et al. Sodium fusidate in Gillain-Barre syndrome: A case report. Journal of Neurology, Neurosurgery and Psychiatry. 1998;65(2):266-268.
Nicoletti, F. ; Nicoletti, A. ; Giuffrida, S. ; Di Marco, R. ; Meroni, P. L. ; Bendtzen, K. ; Lunetta, M. / Sodium fusidate in Gillain-Barre syndrome : A case report. In: Journal of Neurology, Neurosurgery and Psychiatry. 1998 ; Vol. 65, No. 2. pp. 266-268.
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