Sodium metabolism in offspring of hypertensive parents

L. Mazzanti, R. A. Rabini, I. Testa, G. V. Coppa, C. Catassi, M. Cecconi, P. L. Giorgi

Research output: Contribution to journalArticlepeer-review


Intracellular sodium concentration and Na+ K+-ATPase activity were studied in erythrocytes obtained from members of 14 families with one hypertensive parent and from agematched control subjects, as part of a study on the genetic and environmental determinants of essential hypertension. We found reduced Na+ K+-ATPase activity, increased intracellular Na+ concentration, and reduced urinary Na+ excretion in hypertensive patients as compared with the control subjects. In the offspring of hypertensive parents an increase in intracellular Na+ concentration and a decrease in Na+ K+-ATPase activity were observed, with a significant correlation relating such parameters. Normotensive spouses did not differ from the normotensive control adults in any of the parameters studied, suggesting no influence of shared family environment in our family group. These data suggest that there is a strong genetic influence contributing to familiar alterations in cation transport, although long-term studies are needed to evaluate the influence of environmental determinants.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalBiochemical Medicine and Metabolic Biology
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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