Sodium nitroprusside and intracranial pressure

C. Anile, F. Zanghi, A. Bracali, G. Maira, G. F. Rossi

Research output: Contribution to journalArticlepeer-review


The effects of sodium nitroprusside on intracranial pressure were studied in 10 patients, candidates for surgical treatment, prior to anaesthesia. Blood pressure was lowered to at least 50% of its initial value. In all cases, at the beginning of nitroprusside infusion, both the mean and the pulse intracranial pressures increased (mean increase: 83.2% of the initial value). At a certain moment, however, while the blood pressure continued to fall, the mean intracranial pressure did not increase any more; on the contrary, it decreased. On the other hand, in many cases, the pulse intracranial pressure continued to increase. No neurological or EEG changes were observed. The possible changes of cerebral circulation and CSF dynamics underlying the phenomena observed are discussed.

Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalActa Neurochirurgica
Issue number3-4
Publication statusPublished - Sep 1981


  • blood pressure
  • intracranial pressure
  • Sodium nitroprusside

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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