Sistemi di trasporto transmembrana del Na + in forme diverse di iperlipoproteinemia

Translated title of the contribution: Sodium transport systems in different types of hyperlipoproteinaemia

A. Saitta, M. N. Saitta, A. Messina, M. Bonaiuto, M. Castaldo, M. Cinquegrani, E. Imbalzano, C. Mangano, G. Giordano, G. Vollero, A. Sardo, S. Totaro

Research output: Contribution to journalArticle

Abstract

The possible interrelationships between the erythrocytic transport systems of Na + (Na +/K + pump, Na +/K + cotransport, Na +/Li + countertransport, Na + passive permeability) and the plasmatic lipids (cholesterol, triglycerides, HDL, LDL, apoprotein A1, apoprotein B) were studied in 42 normotensive subjects with different forms of hyperlipoproteinaemia and with a negative familiarity for arterial hypertension. In subjects with hypercholesterolaemia (hyperlipoproteinaemia II A and II B) an elevated activity of the Na +/K + pump was noticed, while in subjects with hypertriglyceridaemia (type IV) an increase in Na + passive permeability and Na +/Li + countertransport with a lower level of intraerythrocytic Na + was shown. A negative correlation was observed between the total efflux of Na + and Na +/K + pump and the levels of cholesterol (r = -0.43, p <0.04 and r = -0.41, p <0.05) and the apoprotein B/A ratio (r = -0.42, p <0.05 and r = -0.50, p <0.01). A negative correlation was also noticed between the Na +/K + pump and the levels of apoprotein B (r = -0.41, p <0.05). The Na +/K + cotransport appeared inversely correlated with the levels of HDL cholesterol (r = -0.42, p <0.05), while the Na + passive permeability was negatively correlated with the levels of LDL (r = -0.43, p <0.04) and positively correlated with the plasmatic triglycerides (r = +0.54, p <0.01). Such data show that the plasmatic lipids can influence the systems of transmembrane ionic transport of Na + and play an important role also this way, in cardiovascular pathology.

Translated title of the contributionSodium transport systems in different types of hyperlipoproteinaemia
Original languageItalian
Pages (from-to)449-454
Number of pages6
JournalMinerva Medica
Volume87
Issue number10
Publication statusPublished - Oct 1996

ASJC Scopus subject areas

  • Medicine(all)

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    Saitta, A., Saitta, M. N., Messina, A., Bonaiuto, M., Castaldo, M., Cinquegrani, M., Imbalzano, E., Mangano, C., Giordano, G., Vollero, G., Sardo, A., & Totaro, S. (1996). Sistemi di trasporto transmembrana del Na + in forme diverse di iperlipoproteinemia. Minerva Medica, 87(10), 449-454.