The possible interrelationships between the erythrocytic transport systems of Na + (Na +/K + pump, Na +/K + cotransport, Na +/Li + countertransport, Na + passive permeability) and the plasmatic lipids (cholesterol, triglycerides, HDL, LDL, apoprotein A1, apoprotein B) were studied in 42 normotensive subjects with different forms of hyperlipoproteinaemia and with a negative familiarity for arterial hypertension. In subjects with hypercholesterolaemia (hyperlipoproteinaemia II A and II B) an elevated activity of the Na +/K + pump was noticed, while in subjects with hypertriglyceridaemia (type IV) an increase in Na + passive permeability and Na +/Li + countertransport with a lower level of intraerythrocytic Na + was shown. A negative correlation was observed between the total efflux of Na + and Na +/K + pump and the levels of cholesterol (r = -0.43, p <0.04 and r = -0.41, p <0.05) and the apoprotein B/A ratio (r = -0.42, p <0.05 and r = -0.50, p <0.01). A negative correlation was also noticed between the Na +/K + pump and the levels of apoprotein B (r = -0.41, p <0.05). The Na +/K + cotransport appeared inversely correlated with the levels of HDL cholesterol (r = -0.42, p <0.05), while the Na + passive permeability was negatively correlated with the levels of LDL (r = -0.43, p <0.04) and positively correlated with the plasmatic triglycerides (r = +0.54, p <0.01). Such data show that the plasmatic lipids can influence the systems of transmembrane ionic transport of Na + and play an important role also this way, in cardiovascular pathology.
|Translated title of the contribution||Sodium transport systems in different types of hyperlipoproteinaemia|
|Number of pages||6|
|Publication status||Published - Oct 1996|
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