Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study

M. Grazia Marciani, M. C E Maschio, F. Spanedda, G. L. Gigli, M. A. Bassetti, G. Bernardi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Seventeen epileptic patients suffering from generalized idiopathic epilepsy who underwent antiepileptic treatment with sodium valproate (NaVPA) for the first time were studied. The EEG was recorded at rest with eyes closed (EC), during blocking reaction, fixation and mental arithmetic tasks. The computerized EEG study, performed before and after therapy, utilized spectral analysis; data underwent statistical evaluation including ANOVA and correlation analysis. Before NaVPA therapy, a significant decrease of beta 1 and beta 2 relative power, compared with control subjects, was observed in epileptic patients at rest with EC, whereas fast activity increased during mental tasks. After treatment, no significant variations in fast activity were observed during tasks, with a pattern similar to that observed in the control population. Therefore, considering the effect of NaVPA primarily on fast activity, which reflects rather well preserved mental functioning processes, it is possible to hypothesize that the drug interferes positively with mental activities,

Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalNeuropsychobiology
Volume31
Issue number4
Publication statusPublished - 1995

Fingerprint

Mental Processes
Valproic Acid
Electroencephalography
Therapeutics
Anticonvulsants
Analysis of Variance
Pharmaceutical Preparations
Population

Keywords

  • Cognitive tasks
  • EEG
  • Sodium valproate
  • Spectral analysis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Grazia Marciani, M., Maschio, M. C. E., Spanedda, F., Gigli, G. L., Bassetti, M. A., & Bernardi, G. (1995). Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study. Neuropsychobiology, 31(4), 210-215.

Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study. / Grazia Marciani, M.; Maschio, M. C E; Spanedda, F.; Gigli, G. L.; Bassetti, M. A.; Bernardi, G.

In: Neuropsychobiology, Vol. 31, No. 4, 1995, p. 210-215.

Research output: Contribution to journalArticle

Grazia Marciani, M, Maschio, MCE, Spanedda, F, Gigli, GL, Bassetti, MA & Bernardi, G 1995, 'Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study', Neuropsychobiology, vol. 31, no. 4, pp. 210-215.
Grazia Marciani M, Maschio MCE, Spanedda F, Gigli GL, Bassetti MA, Bernardi G. Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study. Neuropsychobiology. 1995;31(4):210-215.
Grazia Marciani, M. ; Maschio, M. C E ; Spanedda, F. ; Gigli, G. L. ; Bassetti, M. A. ; Bernardi, G. / Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study. In: Neuropsychobiology. 1995 ; Vol. 31, No. 4. pp. 210-215.
@article{7786493764984caebb34e6bcc2725b5e,
title = "Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study",
abstract = "Seventeen epileptic patients suffering from generalized idiopathic epilepsy who underwent antiepileptic treatment with sodium valproate (NaVPA) for the first time were studied. The EEG was recorded at rest with eyes closed (EC), during blocking reaction, fixation and mental arithmetic tasks. The computerized EEG study, performed before and after therapy, utilized spectral analysis; data underwent statistical evaluation including ANOVA and correlation analysis. Before NaVPA therapy, a significant decrease of beta 1 and beta 2 relative power, compared with control subjects, was observed in epileptic patients at rest with EC, whereas fast activity increased during mental tasks. After treatment, no significant variations in fast activity were observed during tasks, with a pattern similar to that observed in the control population. Therefore, considering the effect of NaVPA primarily on fast activity, which reflects rather well preserved mental functioning processes, it is possible to hypothesize that the drug interferes positively with mental activities,",
keywords = "Cognitive tasks, EEG, Sodium valproate, Spectral analysis",
author = "{Grazia Marciani}, M. and Maschio, {M. C E} and F. Spanedda and Gigli, {G. L.} and Bassetti, {M. A.} and G. Bernardi",
year = "1995",
language = "English",
volume = "31",
pages = "210--215",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study

AU - Grazia Marciani, M.

AU - Maschio, M. C E

AU - Spanedda, F.

AU - Gigli, G. L.

AU - Bassetti, M. A.

AU - Bernardi, G.

PY - 1995

Y1 - 1995

N2 - Seventeen epileptic patients suffering from generalized idiopathic epilepsy who underwent antiepileptic treatment with sodium valproate (NaVPA) for the first time were studied. The EEG was recorded at rest with eyes closed (EC), during blocking reaction, fixation and mental arithmetic tasks. The computerized EEG study, performed before and after therapy, utilized spectral analysis; data underwent statistical evaluation including ANOVA and correlation analysis. Before NaVPA therapy, a significant decrease of beta 1 and beta 2 relative power, compared with control subjects, was observed in epileptic patients at rest with EC, whereas fast activity increased during mental tasks. After treatment, no significant variations in fast activity were observed during tasks, with a pattern similar to that observed in the control population. Therefore, considering the effect of NaVPA primarily on fast activity, which reflects rather well preserved mental functioning processes, it is possible to hypothesize that the drug interferes positively with mental activities,

AB - Seventeen epileptic patients suffering from generalized idiopathic epilepsy who underwent antiepileptic treatment with sodium valproate (NaVPA) for the first time were studied. The EEG was recorded at rest with eyes closed (EC), during blocking reaction, fixation and mental arithmetic tasks. The computerized EEG study, performed before and after therapy, utilized spectral analysis; data underwent statistical evaluation including ANOVA and correlation analysis. Before NaVPA therapy, a significant decrease of beta 1 and beta 2 relative power, compared with control subjects, was observed in epileptic patients at rest with EC, whereas fast activity increased during mental tasks. After treatment, no significant variations in fast activity were observed during tasks, with a pattern similar to that observed in the control population. Therefore, considering the effect of NaVPA primarily on fast activity, which reflects rather well preserved mental functioning processes, it is possible to hypothesize that the drug interferes positively with mental activities,

KW - Cognitive tasks

KW - EEG

KW - Sodium valproate

KW - Spectral analysis

UR - http://www.scopus.com/inward/record.url?scp=0028999451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028999451&partnerID=8YFLogxK

M3 - Article

C2 - 7659204

AN - SCOPUS:0028999451

VL - 31

SP - 210

EP - 215

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 4

ER -