Background. The prevalence of Adverse Drug Reactions increases with advancing age. Few studies have evaluated the association between NSAID or Coxib use and gastrointestinal (GI) symptoms and prescriptions in ambulatory care elderly patients. Methods. The study was carried out by 133 GPs referring to 24 Geriatric Units in Italy. By using a structured interview, the following parameters were recorded from all elderly subjects who referred to their GPs: sex, age, ADL, IADL, current medications and new drug prescriptions (according to the ATC classification), GI symptoms (according to the Gastrointestinal Symptom Rating Scale, GSRS) and diagnostic procedures occurred during the last 6-month period. Results. The prevalence of drug use was 91.6%. The mean number of drugs was 2.86/person. Either the prevalences and the mean number of drugs significantly increased with advancing age. A significantly higher prevalence of upper GI symptoms was observed in elderly NSAID users compared to Coxib users and non-users of musculo-skeletal drugs (43.7% vs. 32.7% vs. 32.1%, p = 0.0001). A significant association between GI drug prescriptions and upper GI symptoms (OR = 1.7, 95% CI = 1.6-1.9), previous GI disorders (OR = 1.1, 95% CI = 1.0-1.3) and NSAID use (OR = 1.5, 95% CI = 1.0-2.2) was observed. Conclusion. In this elderly population, drug use is very high; NSAID use was associated with higher upper GI symptoms and the prescriptions of GI drugs than Coxib use.
|Translated title of the contribution||S.O.F.I.A. project: Observational study on drug use in the elderly outpatients in Italy|
|Number of pages||7|
|Journal||Giornale di Gerontologia|
|Publication status||Published - Oct 2004|
ASJC Scopus subject areas
- Geriatrics and Gerontology