Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy: preliminary results

Daniela Alterio; Marta Tagliabue; Matteo Muto; Stefano Zorzi; Stefania Volpe; Sara Gandini; Daniela Sibio; Ömer Bayır; Giulia Marvaso; Annamaria Ferrari; Roberto Bruschini; Maria Cossu Rocca; Lorenzo Preda; Roberta Marangoni; Anna Starzynska; Sabrina Vigorito; Mohssen Ansarin; Barbara Alicja Jereczek-Fossa

doi:10.1177/0300891619900920

Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy: preliminary results

Daniela Alterio, Marta Tagliabue, Matteo Muto, Stefano Zorzi, Stefania Volpe, Sara Gandini, Daniela Sibio, Ömer Bayır, Giulia Marvaso, Annamaria Ferrari, Roberto Bruschini, Maria Cossu Rocca, Lorenzo Preda, Roberta Marangoni, Anna Starzynska, Sabrina Vigorito, Mohssen Ansarin, Barbara Alicja Jereczek-Fossa

Research output: Contribution to journal › Article

Abstract

Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). Methods: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded. Results: No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes (p = 0.05). Conclusion: We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.

Original language	English
Journal	Tumori
DOIs	https://doi.org/10.1177/0300891619900920
Publication status	Accepted/In press - Jan 1 2020

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Keywords

Oropharyngeal cancer
postoperative radiotherapy
soft tissue necrosis
supraglottic laryngeal cancer
transoral robotic surgery

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

Alterio, D., Tagliabue, M., Muto, M., Zorzi, S., Volpe, S., Gandini, S., Sibio, D., Bayır, Ö., Marvaso, G., Ferrari, A., Bruschini, R., Cossu Rocca, M., Preda, L., Marangoni, R., Starzynska, A., Vigorito, S., Ansarin, M., & Jereczek-Fossa, B. A. (Accepted/In press). Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy: preliminary results. Tumori. https://doi.org/10.1177/0300891619900920

Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy : preliminary results. / Alterio, Daniela ; Tagliabue, Marta; Muto, Matteo; Zorzi, Stefano ; Volpe, Stefania ; Gandini, Sara; Sibio, Daniela; Bayır, Ömer; Marvaso, Giulia ; Ferrari, Annamaria ; Bruschini, Roberto ; Cossu Rocca, Maria ; Preda, Lorenzo; Marangoni, Roberta; Starzynska, Anna; Vigorito, Sabrina ; Ansarin, Mohssen ; Jereczek-Fossa, Barbara Alicja.

In: Tumori, 01.01.2020.

Research output: Contribution to journal › Article

Alterio, D , Tagliabue, M, Muto, M, Zorzi, S , Volpe, S , Gandini, S, Sibio, D, Bayır, Ö, Marvaso, G , Ferrari, A , Bruschini, R , Cossu Rocca, M , Preda, L, Marangoni, R, Starzynska, A, Vigorito, S , Ansarin, M & Jereczek-Fossa, BA 2020, 'Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy: preliminary results', Tumori. https://doi.org/10.1177/0300891619900920

Alterio, Daniela ; Tagliabue, Marta ; Muto, Matteo ; Zorzi, Stefano ; Volpe, Stefania ; Gandini, Sara ; Sibio, Daniela ; Bayır, Ömer ; Marvaso, Giulia ; Ferrari, Annamaria ; Bruschini, Roberto ; Cossu Rocca, Maria ; Preda, Lorenzo ; Marangoni, Roberta ; Starzynska, Anna ; Vigorito, Sabrina ; Ansarin, Mohssen ; Jereczek-Fossa, Barbara Alicja. / Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy : preliminary results. In: Tumori. 2020.

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abstract = "Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). Methods: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded. Results: No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes (p = 0.05). Conclusion: We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.",

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AU - Alterio, Daniela

AU - Tagliabue, Marta

AU - Muto, Matteo

AU - Zorzi, Stefano

AU - Volpe, Stefania

AU - Gandini, Sara

AU - Sibio, Daniela

AU - Bayır, Ömer

AU - Marvaso, Giulia

AU - Ferrari, Annamaria

AU - Bruschini, Roberto

AU - Cossu Rocca, Maria

AU - Preda, Lorenzo

AU - Marangoni, Roberta

AU - Starzynska, Anna

AU - Vigorito, Sabrina

AU - Ansarin, Mohssen

AU - Jereczek-Fossa, Barbara Alicja

PY - 2020/1/1

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N2 - Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). Methods: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded. Results: No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes (p = 0.05). Conclusion: We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.

AB - Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). Methods: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded. Results: No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes (p = 0.05). Conclusion: We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.

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KW - supraglottic laryngeal cancer

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