TY - JOUR
T1 - Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy
T2 - preliminary results
AU - Alterio, Daniela
AU - Tagliabue, Marta
AU - Muto, Matteo
AU - Zorzi, Stefano
AU - Volpe, Stefania
AU - Gandini, Sara
AU - Sibio, Daniela
AU - Bayır, Ömer
AU - Marvaso, Giulia
AU - Ferrari, Annamaria
AU - Bruschini, Roberto
AU - Cossu Rocca, Maria
AU - Preda, Lorenzo
AU - Marangoni, Roberta
AU - Starzynska, Anna
AU - Vigorito, Sabrina
AU - Ansarin, Mohssen
AU - Jereczek-Fossa, Barbara Alicja
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). Methods: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded. Results: No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes (p = 0.05). Conclusion: We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.
AB - Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). Methods: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded. Results: No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes (p = 0.05). Conclusion: We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.
KW - Oropharyngeal cancer
KW - postoperative radiotherapy
KW - soft tissue necrosis
KW - supraglottic laryngeal cancer
KW - transoral robotic surgery
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U2 - 10.1177/0300891619900920
DO - 10.1177/0300891619900920
M3 - Article
C2 - 31996091
AN - SCOPUS:85078732687
JO - Tumori
JF - Tumori
SN - 0300-8916
ER -