Soft tissue response to a new austenitic stainless steel with a negligible nickel content

M. Tschon, M. Fini, G. Giavaresi, V. Borsari, H. Lenger, J. Bernauer, R. Chiesa, A. Cigada, L. Chiusoli, Roberto Giardino

Research output: Contribution to journalArticlepeer-review

Abstract

This study evaluates the soft tissue response to a new austenitic stainless steel with a low nickel content (P558) in comparison with a conventional stainless steel (SSt) and a titanium alloy (Ti6Al4V). Previous findings showed its in vitro biocompatibility by culturing P558 with healthy and osteoporotic osteoblasts and its in vivo effectiveness as bone implant material. Regarding its use as a material in osteosynthesis, P558 biocompatibility when implanted in soft tissues, as subcutis and muscle, was assessed. Disks and rods of these metals were implanted in rat subcutis and in rabbit muscle, respectively. Four and twelve weeks post surgery implants with surrounding tissue were retrieved for histologic and histomorphometric analysis: fibrous capsule thickness and new vessel formation were measured. Around all implanted materials, light microscopy highlighted a reactive and fibrous capsule formation coupled with ongoing neoangiogenesis both in rats and in rabbits. Histomorphometric measurements revealed a stronger inflammatory response, in terms of capsule thickness, surrounding SSt implants (9.8% Ni content) both in rat subcutis and in rabbit muscle independently of shape and site of implantation. A progressive decrease in capsule thickness around P558 (

Original languageEnglish
Pages (from-to)1003-1011
Number of pages9
JournalInternational Journal of Artificial Organs
Volume28
Issue number10
Publication statusPublished - Oct 2005

Keywords

  • Fibrous capsule
  • Implant
  • Neoangiogenesis
  • Nickel-reduced stainless steel
  • Stainless steel
  • Titanium alloy

ASJC Scopus subject areas

  • Biophysics

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