Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients

Giacomo Novara; Robert S. Svatek; Pierre I. Karakiewicz; Eila Skinner; Vincenzo Ficarra; Yves Fradet; Yair Lotan; Hendrik Isbarn; Umberto Capitanio; Patrick J. Bastian; Wassim Kassouf; Hans Martin Fritsche; Jonathan I. Izawa; Derya Tilki; Colin P. Dinney; Seth P. Lerner; Mark Schoenberg; Bjoern G. Volkmer; Arthur I. Sagalowsky; Shahrokh F. Shariat

doi:10.1016/j.juro.2010.02.021

Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients

Giacomo Novara, Robert S. Svatek, Pierre I. Karakiewicz, Eila Skinner, Vincenzo Ficarra, Yves Fradet, Yair Lotan, Hendrik Isbarn, Umberto Capitanio, Patrick J. Bastian, Wassim Kassouf, Hans Martin Fritsche, Jonathan I. Izawa, Derya Tilki, Colin P. Dinney, Seth P. Lerner, Mark Schoenberg, Bjoern G. Volkmer, Arthur I. Sagalowsky, Shahrokh F. Shariat

IRCCS Ospedale San Raffaele

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Abstract

Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3%). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p

Original language	English
Pages (from-to)	2165-2170
Number of pages	6
Journal	Journal of Urology
Volume	183
Issue number	6
DOIs	https://doi.org/10.1016/j.juro.2010.02.021
Publication status	Published - Jun 2010

Keywords

carcinoma
cystectomy
prognosis
survival
transitional cell
urinary bladder neoplasms

ASJC Scopus subject areas

Urology

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10.1016/j.juro.2010.02.021

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Novara, G., Svatek, R. S., Karakiewicz, P. I., Skinner, E., Ficarra, V., Fradet, Y., Lotan, Y., Isbarn, H., Capitanio, U., Bastian, P. J., Kassouf, W., Fritsche, H. M., Izawa, J. I., Tilki, D., Dinney, C. P., Lerner, S. P., Schoenberg, M., Volkmer, B. G., Sagalowsky, A. I., & Shariat, S. F. (2010). Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients. Journal of Urology, 183(6), 2165-2170. https://doi.org/10.1016/j.juro.2010.02.021

Novara, G, Svatek, RS, Karakiewicz, PI, Skinner, E, Ficarra, V, Fradet, Y, Lotan, Y, Isbarn, H, Capitanio, U, Bastian, PJ, Kassouf, W, Fritsche, HM, Izawa, JI, Tilki, D, Dinney, CP, Lerner, SP, Schoenberg, M, Volkmer, BG, Sagalowsky, AI & Shariat, SF 2010, 'Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients', Journal of Urology, vol. 183, no. 6, pp. 2165-2170. https://doi.org/10.1016/j.juro.2010.02.021

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title = "Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients",

abstract = "Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3%). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p ",

keywords = "carcinoma, cystectomy, prognosis, survival, transitional cell, urinary bladder neoplasms",

author = "Giacomo Novara and Svatek, {Robert S.} and Karakiewicz, {Pierre I.} and Eila Skinner and Vincenzo Ficarra and Yves Fradet and Yair Lotan and Hendrik Isbarn and Umberto Capitanio and Bastian, {Patrick J.} and Wassim Kassouf and Fritsche, {Hans Martin} and Izawa, {Jonathan I.} and Derya Tilki and Dinney, {Colin P.} and Lerner, {Seth P.} and Mark Schoenberg and Volkmer, {Bjoern G.} and Sagalowsky, {Arthur I.} and Shariat, {Shahrokh F.}",

year = "2010",

month = jun,

doi = "10.1016/j.juro.2010.02.021",

language = "English",

volume = "183",

pages = "2165--2170",

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T1 - Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy

T2 - A Multicenter Study of More Than 4,400 Patients

AU - Novara, Giacomo

AU - Svatek, Robert S.

AU - Karakiewicz, Pierre I.

AU - Skinner, Eila

AU - Ficarra, Vincenzo

AU - Fradet, Yves

AU - Lotan, Yair

AU - Isbarn, Hendrik

AU - Capitanio, Umberto

AU - Bastian, Patrick J.

AU - Kassouf, Wassim

AU - Fritsche, Hans Martin

AU - Izawa, Jonathan I.

AU - Tilki, Derya

AU - Dinney, Colin P.

AU - Lerner, Seth P.

AU - Schoenberg, Mark

AU - Volkmer, Bjoern G.

AU - Sagalowsky, Arthur I.

AU - Shariat, Shahrokh F.

PY - 2010/6

Y1 - 2010/6

N2 - Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3%). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p

AB - Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3%). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p

KW - carcinoma

KW - cystectomy

KW - prognosis

KW - survival

KW - transitional cell

KW - urinary bladder neoplasms

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Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients

Abstract

Keywords

ASJC Scopus subject areas

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