Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients

Giacomo Novara, Robert S. Svatek, Pierre I. Karakiewicz, Eila Skinner, Vincenzo Ficarra, Yves Fradet, Yair Lotan, Hendrik Isbarn, Umberto Capitanio, Patrick J. Bastian, Wassim Kassouf, Hans Martin Fritsche, Jonathan I. Izawa, Derya Tilki, Colin P. Dinney, Seth P. Lerner, Mark Schoenberg, Bjoern G. Volkmer, Arthur I. Sagalowsky, Shahrokh F. Shariat

Research output: Contribution to journalArticle

Abstract

Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3%). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p

Original languageEnglish
Pages (from-to)2165-2170
Number of pages6
JournalJournal of Urology
Volume183
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords

  • carcinoma
  • cystectomy
  • prognosis
  • survival
  • transitional cell
  • urinary bladder neoplasms

ASJC Scopus subject areas

  • Urology

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    Novara, G., Svatek, R. S., Karakiewicz, P. I., Skinner, E., Ficarra, V., Fradet, Y., Lotan, Y., Isbarn, H., Capitanio, U., Bastian, P. J., Kassouf, W., Fritsche, H. M., Izawa, J. I., Tilki, D., Dinney, C. P., Lerner, S. P., Schoenberg, M., Volkmer, B. G., Sagalowsky, A. I., & Shariat, S. F. (2010). Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients. Journal of Urology, 183(6), 2165-2170. https://doi.org/10.1016/j.juro.2010.02.021