Abstract
Vascular endothelial growth factor (VEGF) was proposed as a target for antiangiogenetic therapy in high-grade gliomas. We tested the efficacy of solid lipid nanoparticles (SLNs) carrying VEGF antisense oligonucleotides to down-regulate VEGF expression in an in vitro and in vivo rat glioma model. In vitro: rat C6 glioma cells under hypoxic conditions were treated with VEGF antisense oligonucleotides, either free or vehiculated by SLNs at different concentrations for 24 and 48 hours. At Western blot analysis, cellular VEGF expression was significantly reduced (p
Original language | English |
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Pages (from-to) | 65-74 |
Number of pages | 10 |
Journal | Journal of Nanoneuroscience |
Volume | 1 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- Antisense oligonucleotides
- C6 glioma cells
- Glioma
- Solid lipid nanoparticles
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Neuroscience (miscellaneous)