Solid lipid nanoparticles carrying oligonucleotides inhibit vascular endothelial growth factor expression in rat glioma models

Andrea M. Brioschi; Sara Calderoni; Luca G. Pradotto; Marilena Guido; Alberto Strada; Francesco Zenga; Carlo Alberto Benech; Franco Benech; Loredana Serpe; Gian Paolo Zara; Claudia Musicanti; Alessandro Ducati; Maria Rosa Gasco; Alessandro Mauro

doi:10.1166/jns.2009.007

Solid lipid nanoparticles carrying oligonucleotides inhibit vascular endothelial growth factor expression in rat glioma models

Andrea M. Brioschi, Sara Calderoni, Luca G. Pradotto, Marilena Guido, Alberto Strada, Francesco Zenga, Carlo Alberto Benech, Franco Benech, Loredana Serpe, Gian Paolo Zara, Claudia Musicanti, Alessandro Ducati, Maria Rosa Gasco, Alessandro Mauro

Research output: Contribution to journal › Article

Abstract

Vascular endothelial growth factor (VEGF) was proposed as a target for antiangiogenetic therapy in high-grade gliomas. We tested the efficacy of solid lipid nanoparticles (SLNs) carrying VEGF antisense oligonucleotides to down-regulate VEGF expression in an in vitro and in vivo rat glioma model. In vitro: rat C6 glioma cells under hypoxic conditions were treated with VEGF antisense oligonucleotides, either free or vehiculated by SLNs at different concentrations for 24 and 48 hours. At Western blot analysis, cellular VEGF expression was significantly reduced (p

Original language	English
Pages (from-to)	65-74
Number of pages	10
Journal	Journal of Nanoneuroscience
Volume	1
Issue number	1
DOIs	https://doi.org/10.1166/jns.2009.007
Publication status	Published - 2009

Keywords

Antisense oligonucleotides
C6 glioma cells
Glioma
Solid lipid nanoparticles
Vascular endothelial growth factor

ASJC Scopus subject areas

Neuroscience (miscellaneous)

Access to Document

10.1166/jns.2009.007

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Brioschi, A. M., Calderoni, S., Pradotto, L. G., Guido, M., Strada, A., Zenga, F., Benech, C. A., Benech, F., Serpe, L., Zara, G. P., Musicanti, C., Ducati, A., Gasco, M. R., & Mauro, A. (2009). Solid lipid nanoparticles carrying oligonucleotides inhibit vascular endothelial growth factor expression in rat glioma models. Journal of Nanoneuroscience, 1(1), 65-74. https://doi.org/10.1166/jns.2009.007

Solid lipid nanoparticles carrying oligonucleotides inhibit vascular endothelial growth factor expression in rat glioma models. / Brioschi, Andrea M.; Calderoni, Sara ; Pradotto, Luca G.; Guido, Marilena; Strada, Alberto; Zenga, Francesco; Benech, Carlo Alberto; Benech, Franco; Serpe, Loredana; Zara, Gian Paolo; Musicanti, Claudia; Ducati, Alessandro; Gasco, Maria Rosa; Mauro, Alessandro.

In: Journal of Nanoneuroscience, Vol. 1, No. 1, 2009, p. 65-74.

Research output: Contribution to journal › Article

Brioschi, AM, Calderoni, S , Pradotto, LG, Guido, M, Strada, A, Zenga, F, Benech, CA, Benech, F, Serpe, L, Zara, GP, Musicanti, C, Ducati, A, Gasco, MR & Mauro, A 2009, 'Solid lipid nanoparticles carrying oligonucleotides inhibit vascular endothelial growth factor expression in rat glioma models', Journal of Nanoneuroscience, vol. 1, no. 1, pp. 65-74. https://doi.org/10.1166/jns.2009.007

Brioschi, Andrea M. ; Calderoni, Sara ; Pradotto, Luca G. ; Guido, Marilena ; Strada, Alberto ; Zenga, Francesco ; Benech, Carlo Alberto ; Benech, Franco ; Serpe, Loredana ; Zara, Gian Paolo ; Musicanti, Claudia ; Ducati, Alessandro ; Gasco, Maria Rosa ; Mauro, Alessandro. / Solid lipid nanoparticles carrying oligonucleotides inhibit vascular endothelial growth factor expression in rat glioma models. In: Journal of Nanoneuroscience. 2009 ; Vol. 1, No. 1. pp. 65-74.

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