Solid lipid nanoparticles: Could they help to improve the efficacy of pharmacologic treatments for brain tumors?

Andrea Brioschi, Francesco Zenga, Gian Paolo Zara, Maria Rosa Gasco, Alessandro Ducati, Alessandro Mauro

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Brain malignant neoplasms are still characterized by poor prognosis due to their peculiar hallmarks that severely limit aggressive multimodal therapeutic approaches. The optimization of the intratumoral drug delivery, directed to achieve effective concentrations and to reduce systemic undesired toxicity, is one of the primary goals of the brain tumors therapeutic strategies. Different passive and active delivery carriers allowing to a better control of drug distribution, metabolism, and elimination after parenteral administration have been developed. In the present review we will describe general characteristics and evaluate the efficacy of Solid Lipid Nanoparticles (SLN) as carriers of different drugs in experimental brain malignant tumor therapy. Methods: SLN vehiculating different illustrative types of antineoplastic agents (conventional cytotoxic drugs such as doxorubicin andpaclitaxel, the prodrug Cholesteryl butyrate, and anti VEGF antisense oligonucleotides) have been tested in experimental animal models of cerebral gliomas. Results: SLN proved to successfully vehiculate into the brain different types of cytotoxic and gene therapeutical agents (otherwise unable to pass through the Blood-Brain Barrier) and to induce effective anti-tumoral therapeutical response. Discussion: Compared to other vehicules, SLN seem to offer more advantages (such as higher physical stability, greater protection from degradation and better release profile of incorporated drugs, good tolerability and possibility of site-specific targeting) and could be regarded as an effective carrier for chemotherapeutic drugs, gene therapeutical agents, and diagnostic tools in neuro-oncology.

Original languageEnglish
Pages (from-to)324-330
Number of pages7
JournalNeurological Research
Volume29
Issue number3
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Antisense Oligonucleotides
  • Chemotherapy
  • Cholesteryl butyrate
  • Doxorubicin
  • Gene therapy
  • Glioma therapy
  • Paclitaxel
  • Solid Lipid Nanoparticles
  • VEGF

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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