Solid lipid nanoparticles for brain tumors therapy: State of the art and novel challenges

Andrea M. Brioschi, Sara Calderoni, Gian Paolo Zara, Lorenzo Priano, Maria Rosa Gasco, Alessandro Mauro

Research output: Contribution to journalArticle

Abstract

Malignant gliomas, despite aggressive multimodal therapies and adequate supportive care, still maintain poor prognosis. Solid lipid nanoparticles (SLN) are colloidal carriers that could be regarded as a highly flexible platform for brain tumor imaging and therapeutical purposes. In this chapter we will first describe brain tumors characteristics and conventional therapeutical approaches. In the subsequent sections, we will analyze SLN properties, effectiveness, and future perspectives in both imaging and targeted treatment of malignant gliomas.

Original languageEnglish
Pages (from-to)193-223
Number of pages31
JournalProgress in Brain Research
Volume180
Issue numberC
DOIs
Publication statusPublished - 2009

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Keywords

  • Angiogenesis
  • Brain tumor imaging
  • Brain tumors
  • Cholesterylbutyrate
  • Drug targeting
  • Solid lipid nanoparticles

ASJC Scopus subject areas

  • Neuroscience(all)

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