Solid-state characterization and dissolution properties of Naproxen-Arginine-Hydroxypropyl-β-cyclodextrin ternary system

Paola Mura, Gian Piero Bettinetti, Marzia Cirri, Francesca Maestrelli, Milena Sorrenti, Laura Catenacci

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of ternary complexation of naproxen, a poorly water soluble anti-inflammatory drug, with hydroxypropyl-β-cyclodextrin and the basic aminoacid L-arginine on the drug dissolution properties has been investigated. Equimolar binary (drug-cyclodextrin or drug-arginine) and ternary (drug-cyclodextrin-arginine) systems were prepared by blending, cogrinding, coevaporation, and characterized by differential scanning calorimetry, thermogravimetric analysis, FT-IR spectroscopy, X-ray diffractometry. The dissolution behavior of naproxen from the different products was evaluated by means of a continuous flow through method. The results of solid state studies indicated the presence of strong interactions between the components in ternary coevaporated and coground systems, which were both of totally amorphous nature. In contrast, the presence of either free drug or free arginine was detected when the third component (cyclodextrin or aminoacid) was physically mixed, respectively, to the drug-arginine binary system (as physical mixture, coevaporate, or coground product) or to the drug-cyclodextrin binary system (as physical mixture, coevaporate, or coground product). All ternary combinations were significantly (P

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Arginine
  • Dissolution rate
  • Hydroxypropyl-β-cyclodextrin
  • Naproxen
  • Ternary system

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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