Solifenacin in women with de novo overactive bladder after tension-free obturator vaginal tape - Is it effective?

Maurizio Serati, Andrea Braga, Paola Sorice, Gabriele Siesto, Stefano Salvatore, Fabio Ghezzi

Research output: Contribution to journalArticle

Abstract

Purpose To our knowledge no group has evaluated antimuscarinic efficacy in patients with de novo overactive bladder after mid urethral sling placement. We assessed solifenacin efficacy in women with de novo overactive bladder after obturator tension-free vaginal tape placement compared to a control group. Materials and Methods We prospectively considered all women with de novo overactive bladder symptoms at a 3-month followup visit after placement of obturator tension-free vaginal tape. Patients with overactive bladder preoperatively and those with obstructive symptoms or signs were excluded from analysis. Women who satisfied inclusion and exclusion criteria (group 1) were compared with a series of consecutive naïve patients with overactive bladder symptoms without a previous surgical procedure for stress urinary incontinence (group 2). We prescribed 12-week antimuscarinic therapy with oral solifenacin 5 mg once daily. Objective outcomes included changes from baseline in 3-day voiding diary data. Subjective efficacy was evaluated using the Overactive Bladder Questionnaire Short Form, Urgency Severity Scale and Patient Global Impression of Improvement questionnaires. Results A total of 110 patients with de novo overactive bladder after obturator tension-free vaginal tape placement completed solifenacin treatment and were included in group 1. They were compared with 120 consecutive naïve women with overactive bladder (group 2). Group 1 presented at the 3-month followup visit with significantly less benefit in the mean decrease in urgency and urgency urinary incontinence episodes daily (-1.1 vs -2.3 and -0.2 vs -1.1, respectively, each p

Original languageEnglish
Pages (from-to)1322-1326
Number of pages5
JournalJournal of Urology
Volume191
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • drug evaluation
  • overactive
  • solifenacin
  • suburethral slings
  • urethra
  • urinary bladder

ASJC Scopus subject areas

  • Urology

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