Solitary cerebral metastasis from melanoma: Value of the 'en bloc' resection

Maurizio Salvati, Luigi Cervoni, Riccardo Caruso, Franco Maria Gagliardi

Research output: Contribution to journalArticlepeer-review


The authors report 19 cases of solitary cerebral metastases from malignant malanoma. In 15 patients, the primary lesion was known at the time the metastasis was diagnosed; deltoid-scapular in 4 cases, thoracic in 5, inguinal in 4 and neck in 2. The primary location was unknown in 4 patients. Presenting symptoms were: epileptic seizures in 9 cases, headache in 8, strength deficit of the limbs in 2. In 3 patients (16%) neurological symptoms were the first clinical sign of the systemic tumor; in 16 cases (84%) there was a long interval between treatment of the primary and appearance of the cerebral metastasis (average 3.8 years; median 3.4 years). All patients were submitted to surgery and radiotherapy (whole-brain in 14 and radiosurgery in 5). In 10 cases the lesion was removed 'en bloc' (no internal touch technique). Average survival was 9 months (median 8 months) and was influenced by 'en bloc' resection and whole-brain irradiation. None of the patients operated by the 'no touch technique' presented a recurrence.

Original languageEnglish
Pages (from-to)12-14
Number of pages3
JournalClinical Neurology and Neurosurgery
Issue number1
Publication statusPublished - Feb 1996


  • Brain
  • Melanoma
  • Single metastasis
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Neurology


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