Solitary fibrous tumor of the central nervous system: A 15-year literature survey of 220 cases (August 1996-July 2011)

Michele Bisceglia, Carlos Galliani, Giuseppe Giannatempo, Walter Lauriola, Mario Bianco, Vincenzo D'Angelo, Stefano Pizzolitto, Giulia Vita, Gianandrea Pasquinelli, Gaetano Magro, David Ben Dor

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Abstract

We reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just over one-fifth are intraspinal. In decreasing frequency, intracranial tumors involve the supratentorial and infratentorial compartments, the pontocerebellar angle, the sellar and parasellar regions, and the cranial nerves. Intraspinal tumors are mainly located in the thoracic and cervical segments. Although most solitary fibrous tumors of the central nervous system are dural based, a small subset presents as subpial, intraparenchymal, intraventricular, or as tumors involving the nerve rootlets with no dural connection. Preoperative imaging and intraoperative findings suggest meningioma, schwannoma or neurofibroma, hemangiopericytoma, or pituitary tumors. Immunohistochemistry is critical to establish a definitive histopathological diagnosis. Vimentin, CD34, BCL2, and CD99 are the most consistently positive markers. The usual histologic type generally behaves in a benign manner if complete removal is achieved. Recurrence is anticipated when resection is subtotal or when the tumor exhibits atypical histology. The proliferative index as assessed by MIB1 labeling is of prognostic significance. Occasionally, tumors featuring conventional morphology may recur, perhaps because of minimal residual disease left behind during surgical extirpation. Rare extracranial metastases and tumor-related deaths are on record. Surgery is the treatment of choice. Stereotactic and external beam radiation therapy may be indicated for postsurgical tumor remnants and for unresectable recurrences. Long-term active surveillance of the patients is mandatory.

Original languageEnglish
Pages (from-to)356-392
Number of pages37
JournalAdvances in Anatomic Pathology
Volume18
Issue number5
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Solitary Fibrous Tumors
Nervous System Neoplasms
Central Nervous System
Neoplasms
Supratentorial Neoplasms
Infratentorial Neoplasms
Hemangiopericytoma
Recurrence
Neurofibroma
Death Certificates
Cranial Nerves
Neurilemmoma
Residual Neoplasm
Pituitary Neoplasms
Meningioma
Vimentin
Surveys and Questionnaires
Histology
Radiotherapy
Thorax

Keywords

  • brain tumor
  • CD34
  • central nervous system
  • meninges
  • solitary fibrous tumor
  • spinal cord tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

Cite this

Bisceglia, M., Galliani, C., Giannatempo, G., Lauriola, W., Bianco, M., D'Angelo, V., ... Dor, D. B. (2011). Solitary fibrous tumor of the central nervous system: A 15-year literature survey of 220 cases (August 1996-July 2011). Advances in Anatomic Pathology, 18(5), 356-392. https://doi.org/10.1097/PAP.0b013e318229c004

Solitary fibrous tumor of the central nervous system : A 15-year literature survey of 220 cases (August 1996-July 2011). / Bisceglia, Michele; Galliani, Carlos; Giannatempo, Giuseppe; Lauriola, Walter; Bianco, Mario; D'Angelo, Vincenzo; Pizzolitto, Stefano; Vita, Giulia; Pasquinelli, Gianandrea; Magro, Gaetano; Dor, David Ben.

In: Advances in Anatomic Pathology, Vol. 18, No. 5, 09.2011, p. 356-392.

Research output: Contribution to journalArticle

Bisceglia, M, Galliani, C, Giannatempo, G, Lauriola, W, Bianco, M, D'Angelo, V, Pizzolitto, S, Vita, G, Pasquinelli, G, Magro, G & Dor, DB 2011, 'Solitary fibrous tumor of the central nervous system: A 15-year literature survey of 220 cases (August 1996-July 2011)', Advances in Anatomic Pathology, vol. 18, no. 5, pp. 356-392. https://doi.org/10.1097/PAP.0b013e318229c004
Bisceglia, Michele ; Galliani, Carlos ; Giannatempo, Giuseppe ; Lauriola, Walter ; Bianco, Mario ; D'Angelo, Vincenzo ; Pizzolitto, Stefano ; Vita, Giulia ; Pasquinelli, Gianandrea ; Magro, Gaetano ; Dor, David Ben. / Solitary fibrous tumor of the central nervous system : A 15-year literature survey of 220 cases (August 1996-July 2011). In: Advances in Anatomic Pathology. 2011 ; Vol. 18, No. 5. pp. 356-392.
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