Solitary Fibrous Tumors of the Pleura

An Analysis of 110 Patients Treated in a Single Institution

Giuseppe Cardillo, Luigi Carbone, Francesco Carleo, Nicola Masala, Paolo Graziano, Antonio Bray, Massimo Martelli

Research output: Contribution to journalArticle

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Abstract

Background: Solitary (localized) fibrous tumors of the pleura (SFTP) are rare slow-growing neoplasms that generally have a favorable prognosis. The aim of this paper is to evaluate the predictors of outcome in a series of 110 patients with SFTP. Methods: The records of 110 patients (63 men; mean age 56.4 years; range, 17 to 79) surgically treated for SFTP from July 1990 to February 2008, were evaluated for demographics, operative procedure, histopathology, morbidity, mortality, postoperative chemotherapy or radiotherapy, and long-term follow-up. Results: Operative mortality was 0.9% (1 of 110) and the overall morbidity was 10.9% (12 of 110). The main surgical approach was video-assisted thoracoscopic surgery (69 procedures with a conversion rate of 14.5%); 40 patients underwent thoracotomy and 1 had sternotomy. The visceral pleura was the site of origin in 95 tumors, the parietal pleura in 13, the mediastinal pleura in 2 cases. Sixty-three tumors were pedunculated, 35 were sessile, and 12 were inverted fibroma. Tumors were pathologically benign in 95 cases (86.4%), and malignant in 15 (13.6%). Symptomatic patients presented with malignant tumors more often than asymptomatic (19.1% versus 9.5%). Overall 10-year survival rate was 97.5%. The overall disease-free survival rate was 90.8% (95.7% in benign cases and 67.1% in malignant cases; p <0.05). Eight patients presented with recurrence of disease, 4 cases of which were malignant and 4 were benign. Conclusions: Solitary fibrous tumor of the pleura is a rare disease that includes both benign and malignant variants.The outcome is mostly benign, with an overall 10-year survival rate of 97.5%. Pathologically benign lesions show a better disease-free survival rate than malignant lesions (95.7% versus 67.1%; p <0.05). Surgery is the gold standard of treatment as neither radiotherapy nor chemotherapy proved to be effective.

Original languageEnglish
Pages (from-to)1632-1637
Number of pages6
JournalAnnals of Thoracic Surgery
Volume88
Issue number5
DOIs
Publication statusPublished - Nov 2009

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Pleural Solitary Fibrous Tumor
Pleura
Survival Rate
Neoplasms
Disease-Free Survival
Radiotherapy
Morbidity
Video-Assisted Thoracic Surgery
Drug Therapy
Sternotomy
Fibroma
Mortality
Operative Surgical Procedures
Thoracotomy
Rare Diseases
Demography
Recurrence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Solitary Fibrous Tumors of the Pleura : An Analysis of 110 Patients Treated in a Single Institution. / Cardillo, Giuseppe; Carbone, Luigi; Carleo, Francesco; Masala, Nicola; Graziano, Paolo; Bray, Antonio; Martelli, Massimo.

In: Annals of Thoracic Surgery, Vol. 88, No. 5, 11.2009, p. 1632-1637.

Research output: Contribution to journalArticle

Cardillo, Giuseppe ; Carbone, Luigi ; Carleo, Francesco ; Masala, Nicola ; Graziano, Paolo ; Bray, Antonio ; Martelli, Massimo. / Solitary Fibrous Tumors of the Pleura : An Analysis of 110 Patients Treated in a Single Institution. In: Annals of Thoracic Surgery. 2009 ; Vol. 88, No. 5. pp. 1632-1637.
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title = "Solitary Fibrous Tumors of the Pleura: An Analysis of 110 Patients Treated in a Single Institution",
abstract = "Background: Solitary (localized) fibrous tumors of the pleura (SFTP) are rare slow-growing neoplasms that generally have a favorable prognosis. The aim of this paper is to evaluate the predictors of outcome in a series of 110 patients with SFTP. Methods: The records of 110 patients (63 men; mean age 56.4 years; range, 17 to 79) surgically treated for SFTP from July 1990 to February 2008, were evaluated for demographics, operative procedure, histopathology, morbidity, mortality, postoperative chemotherapy or radiotherapy, and long-term follow-up. Results: Operative mortality was 0.9{\%} (1 of 110) and the overall morbidity was 10.9{\%} (12 of 110). The main surgical approach was video-assisted thoracoscopic surgery (69 procedures with a conversion rate of 14.5{\%}); 40 patients underwent thoracotomy and 1 had sternotomy. The visceral pleura was the site of origin in 95 tumors, the parietal pleura in 13, the mediastinal pleura in 2 cases. Sixty-three tumors were pedunculated, 35 were sessile, and 12 were inverted fibroma. Tumors were pathologically benign in 95 cases (86.4{\%}), and malignant in 15 (13.6{\%}). Symptomatic patients presented with malignant tumors more often than asymptomatic (19.1{\%} versus 9.5{\%}). Overall 10-year survival rate was 97.5{\%}. The overall disease-free survival rate was 90.8{\%} (95.7{\%} in benign cases and 67.1{\%} in malignant cases; p <0.05). Eight patients presented with recurrence of disease, 4 cases of which were malignant and 4 were benign. Conclusions: Solitary fibrous tumor of the pleura is a rare disease that includes both benign and malignant variants.The outcome is mostly benign, with an overall 10-year survival rate of 97.5{\%}. Pathologically benign lesions show a better disease-free survival rate than malignant lesions (95.7{\%} versus 67.1{\%}; p <0.05). Surgery is the gold standard of treatment as neither radiotherapy nor chemotherapy proved to be effective.",
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T2 - An Analysis of 110 Patients Treated in a Single Institution

AU - Cardillo, Giuseppe

AU - Carbone, Luigi

AU - Carleo, Francesco

AU - Masala, Nicola

AU - Graziano, Paolo

AU - Bray, Antonio

AU - Martelli, Massimo

PY - 2009/11

Y1 - 2009/11

N2 - Background: Solitary (localized) fibrous tumors of the pleura (SFTP) are rare slow-growing neoplasms that generally have a favorable prognosis. The aim of this paper is to evaluate the predictors of outcome in a series of 110 patients with SFTP. Methods: The records of 110 patients (63 men; mean age 56.4 years; range, 17 to 79) surgically treated for SFTP from July 1990 to February 2008, were evaluated for demographics, operative procedure, histopathology, morbidity, mortality, postoperative chemotherapy or radiotherapy, and long-term follow-up. Results: Operative mortality was 0.9% (1 of 110) and the overall morbidity was 10.9% (12 of 110). The main surgical approach was video-assisted thoracoscopic surgery (69 procedures with a conversion rate of 14.5%); 40 patients underwent thoracotomy and 1 had sternotomy. The visceral pleura was the site of origin in 95 tumors, the parietal pleura in 13, the mediastinal pleura in 2 cases. Sixty-three tumors were pedunculated, 35 were sessile, and 12 were inverted fibroma. Tumors were pathologically benign in 95 cases (86.4%), and malignant in 15 (13.6%). Symptomatic patients presented with malignant tumors more often than asymptomatic (19.1% versus 9.5%). Overall 10-year survival rate was 97.5%. The overall disease-free survival rate was 90.8% (95.7% in benign cases and 67.1% in malignant cases; p <0.05). Eight patients presented with recurrence of disease, 4 cases of which were malignant and 4 were benign. Conclusions: Solitary fibrous tumor of the pleura is a rare disease that includes both benign and malignant variants.The outcome is mostly benign, with an overall 10-year survival rate of 97.5%. Pathologically benign lesions show a better disease-free survival rate than malignant lesions (95.7% versus 67.1%; p <0.05). Surgery is the gold standard of treatment as neither radiotherapy nor chemotherapy proved to be effective.

AB - Background: Solitary (localized) fibrous tumors of the pleura (SFTP) are rare slow-growing neoplasms that generally have a favorable prognosis. The aim of this paper is to evaluate the predictors of outcome in a series of 110 patients with SFTP. Methods: The records of 110 patients (63 men; mean age 56.4 years; range, 17 to 79) surgically treated for SFTP from July 1990 to February 2008, were evaluated for demographics, operative procedure, histopathology, morbidity, mortality, postoperative chemotherapy or radiotherapy, and long-term follow-up. Results: Operative mortality was 0.9% (1 of 110) and the overall morbidity was 10.9% (12 of 110). The main surgical approach was video-assisted thoracoscopic surgery (69 procedures with a conversion rate of 14.5%); 40 patients underwent thoracotomy and 1 had sternotomy. The visceral pleura was the site of origin in 95 tumors, the parietal pleura in 13, the mediastinal pleura in 2 cases. Sixty-three tumors were pedunculated, 35 were sessile, and 12 were inverted fibroma. Tumors were pathologically benign in 95 cases (86.4%), and malignant in 15 (13.6%). Symptomatic patients presented with malignant tumors more often than asymptomatic (19.1% versus 9.5%). Overall 10-year survival rate was 97.5%. The overall disease-free survival rate was 90.8% (95.7% in benign cases and 67.1% in malignant cases; p <0.05). Eight patients presented with recurrence of disease, 4 cases of which were malignant and 4 were benign. Conclusions: Solitary fibrous tumor of the pleura is a rare disease that includes both benign and malignant variants.The outcome is mostly benign, with an overall 10-year survival rate of 97.5%. Pathologically benign lesions show a better disease-free survival rate than malignant lesions (95.7% versus 67.1%; p <0.05). Surgery is the gold standard of treatment as neither radiotherapy nor chemotherapy proved to be effective.

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