Solitary lesions of the clivus: what else besides chordomas? An extensive clinical outlook on rare pathologies

Filippo Gagliardi, Alfio Spina, Nicola Boari, Ashwin Narayanan, Pietro Mortini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Solitary non-chordomatous lesions of the clivus are rare pathologies, which represent a diagnostic challenge. This study provides an overview of the clinical, radiological and prognostic characteristics of non-chordomatous clival lesions, highlighting current therapeutic options. Methods: Twenty-two non-chordomatous lesions of the clivus were collected. A retrospective analysis of clinical and radiological patterns as well as survival data was conducted. Results: Clinical presentation was a result of local mass effect. Imaging features, although mainly specific, were not always diagnostic. Extent of surgery was gross total in 45.5 % of cases. Depending on the histology, biological behaviour and presence of seeding, adjuvant treatment was performed, tailoring the treatment strategy to the single patient. Conclusions: Solitary non-chordomatous lesions of the clival bone are more prevalent than expected. They should be approached with a correct differential diagnosis, considering specific epidemiological, radiological, and histopathological characteristics, to minimise diagnostic bias and allow the planning of the best treatment strategy.

Original languageEnglish
Pages (from-to)597-605
Number of pages9
JournalActa Neurochirurgica
Volume157
Issue number4
DOIs
Publication statusPublished - 2015

Keywords

  • Clivus
  • Non-chordomatous lesions
  • Skull base
  • Therapy
  • Tumours

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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