Abstract
The serum levels of soluble β2-μ-associated and β2-μ-free HLA class I heavy chains were determined in 28 interferon-α nonresponder chronic hepatitis C patients retreated with interferon-α plus ribavirin and in 70 healthy subjects. The baseline levels of β2-μ-associated and β2-μ-free HLA class I heavy chains were significantly higher in patients than in healthy controls (P = 0.001). The levels of β2-μ-associated HLA class I heavy chains significantly increased in responder patients with respect to nonresponders at the third month of treatment (P = 0.03). At the sixth month of treatment and after 6 months of follow up the levels of β2-μ-associated HLA class I heavy chains decreased in responder patients and increased in nonresponders. The levels of β2-μ-free HLA class I heavy chains showed only minor changes during and after treatment. We suggest that the determination of hepatitis C virus RNA levels combined with soluble β2-μ-associated HLA class I heavy chains, as a marker of immune activation, could identify interferon-α non responder chronic hepatitis C patients most likely to respond to a retreatment with interferon-α plus ribavirin.
| Original language | English |
|---|---|
| Pages (from-to) | 486-489 |
| Number of pages | 4 |
| Journal | Journal of Clinical Immunology |
| Volume | 20 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Chronic hepatitis C
- Hepatitis C virus RNA
- Interferon-α
- Ribavirin
- Soluble HLA
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Soluble β2-μ-associated and β2-μ-free HLA class I heavy chain serum levels in interferon-α nonresponder chronic hepatitis C patients. Markers of immune activation, and response to antiviral retreatment. / Puppo, Francesco; Torre, Francesco; Contini, Paola; Ghio, Massimo; Brenci, Sabrina; Brizzolara, Renata; Sinelli, Nicoletta; Campo, Nadia; Indiveri, Francesco; Picciotto, Antonino.
In: Journal of Clinical Immunology, Vol. 20, No. 6, 2000, p. 486-489.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Soluble β2-μ-associated and β2-μ-free HLA class I heavy chain serum levels in interferon-α nonresponder chronic hepatitis C patients. Markers of immune activation, and response to antiviral retreatment
AU - Puppo, Francesco
AU - Torre, Francesco
AU - Contini, Paola
AU - Ghio, Massimo
AU - Brenci, Sabrina
AU - Brizzolara, Renata
AU - Sinelli, Nicoletta
AU - Campo, Nadia
AU - Indiveri, Francesco
AU - Picciotto, Antonino
PY - 2000
Y1 - 2000
N2 - The serum levels of soluble β2-μ-associated and β2-μ-free HLA class I heavy chains were determined in 28 interferon-α nonresponder chronic hepatitis C patients retreated with interferon-α plus ribavirin and in 70 healthy subjects. The baseline levels of β2-μ-associated and β2-μ-free HLA class I heavy chains were significantly higher in patients than in healthy controls (P = 0.001). The levels of β2-μ-associated HLA class I heavy chains significantly increased in responder patients with respect to nonresponders at the third month of treatment (P = 0.03). At the sixth month of treatment and after 6 months of follow up the levels of β2-μ-associated HLA class I heavy chains decreased in responder patients and increased in nonresponders. The levels of β2-μ-free HLA class I heavy chains showed only minor changes during and after treatment. We suggest that the determination of hepatitis C virus RNA levels combined with soluble β2-μ-associated HLA class I heavy chains, as a marker of immune activation, could identify interferon-α non responder chronic hepatitis C patients most likely to respond to a retreatment with interferon-α plus ribavirin.
AB - The serum levels of soluble β2-μ-associated and β2-μ-free HLA class I heavy chains were determined in 28 interferon-α nonresponder chronic hepatitis C patients retreated with interferon-α plus ribavirin and in 70 healthy subjects. The baseline levels of β2-μ-associated and β2-μ-free HLA class I heavy chains were significantly higher in patients than in healthy controls (P = 0.001). The levels of β2-μ-associated HLA class I heavy chains significantly increased in responder patients with respect to nonresponders at the third month of treatment (P = 0.03). At the sixth month of treatment and after 6 months of follow up the levels of β2-μ-associated HLA class I heavy chains decreased in responder patients and increased in nonresponders. The levels of β2-μ-free HLA class I heavy chains showed only minor changes during and after treatment. We suggest that the determination of hepatitis C virus RNA levels combined with soluble β2-μ-associated HLA class I heavy chains, as a marker of immune activation, could identify interferon-α non responder chronic hepatitis C patients most likely to respond to a retreatment with interferon-α plus ribavirin.
KW - Chronic hepatitis C
KW - Hepatitis C virus RNA
KW - Interferon-α
KW - Ribavirin
KW - Soluble HLA
UR - http://www.scopus.com/inward/record.url?scp=17744365361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17744365361&partnerID=8YFLogxK
U2 - 10.1023/A:1026468001834
DO - 10.1023/A:1026468001834
M3 - Article
VL - 20
SP - 486
EP - 489
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
SN - 0271-9142
IS - 6
ER -