Soluble adhesion molecules levels in patients with Cushing's syndrome before and after cure

F. Ermetici, A. E. Malavazos, S. Corbetta, C. Eller-Vainicher, S. Cannavò, M. M. Corsi, Bruno Ambrosi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Patients with Cushing's syndrome (CS) show a high prevalence of cardiovascular risk factors and atherosclerosis, persisting even after cure. Soluble intercellular adhesion molecule- I (sICAM-I) and vascular cell adhesion molecule-I (sVCAM-I) are surrogate markers of endothelial function involved in the initiation of atherosclerosis. This study aimed to evaluate sICAM-I and sVCAM-I levels in patients with CS before and after successful cure. Subjects and methods: sICAM-I and sVCAM-I levels were evaluated in 28 patients with active CS and in 12 patients with Cushing's disease (CD), 6-12 months after disease remission. Body mass index (BMI), blood pressure, glucose, serum lipids, ACTH, cortisol and urinary free cortisol (UFC) were measured in basal conditions in all patients. Results: At baseline, sICAM-I levels positively correlated with BMI (r=0.443, p

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalJournal of Endocrinological Investigation
Volume31
Issue number5
Publication statusPublished - May 2008

Keywords

  • Cardiovascular risk
  • Cortisol
  • Cushing's syndrome
  • Endothelial function
  • ICAM-I
  • VCAM-I

ASJC Scopus subject areas

  • Endocrinology

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