Soluble adhesion molecules levels in patients with Cushing's syndrome before and after cure

F. Ermetici; A. E. Malavazos; S. Corbetta; C. Eller-Vainicher; S. Cannavò; M. M. Corsi; Bruno Ambrosi

Soluble adhesion molecules levels in patients with Cushing's syndrome before and after cure

F. Ermetici, A. E. Malavazos, S. Corbetta, C. Eller-Vainicher, S. Cannavò, M. M. Corsi, Bruno Ambrosi

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Patients with Cushing's syndrome (CS) show a high prevalence of cardiovascular risk factors and atherosclerosis, persisting even after cure. Soluble intercellular adhesion molecule- I (sICAM-I) and vascular cell adhesion molecule-I (sVCAM-I) are surrogate markers of endothelial function involved in the initiation of atherosclerosis. This study aimed to evaluate sICAM-I and sVCAM-I levels in patients with CS before and after successful cure. Subjects and methods: sICAM-I and sVCAM-I levels were evaluated in 28 patients with active CS and in 12 patients with Cushing's disease (CD), 6-12 months after disease remission. Body mass index (BMI), blood pressure, glucose, serum lipids, ACTH, cortisol and urinary free cortisol (UFC) were measured in basal conditions in all patients. Results: At baseline, sICAM-I levels positively correlated with BMI (r=0.443, p

Original language	English
Pages (from-to)	389-392
Number of pages	4
Journal	Journal of Endocrinological Investigation
Volume	31
Issue number	5
Publication status	Published - May 2008

Keywords

Cardiovascular risk
Cortisol
Cushing's syndrome
Endothelial function
ICAM-I
VCAM-I

ASJC Scopus subject areas

Endocrinology

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title = "Soluble adhesion molecules levels in patients with Cushing's syndrome before and after cure",

abstract = "Objective: Patients with Cushing's syndrome (CS) show a high prevalence of cardiovascular risk factors and atherosclerosis, persisting even after cure. Soluble intercellular adhesion molecule- I (sICAM-I) and vascular cell adhesion molecule-I (sVCAM-I) are surrogate markers of endothelial function involved in the initiation of atherosclerosis. This study aimed to evaluate sICAM-I and sVCAM-I levels in patients with CS before and after successful cure. Subjects and methods: sICAM-I and sVCAM-I levels were evaluated in 28 patients with active CS and in 12 patients with Cushing's disease (CD), 6-12 months after disease remission. Body mass index (BMI), blood pressure, glucose, serum lipids, ACTH, cortisol and urinary free cortisol (UFC) were measured in basal conditions in all patients. Results: At baseline, sICAM-I levels positively correlated with BMI (r=0.443, p",

keywords = "Cardiovascular risk, Cortisol, Cushing's syndrome, Endothelial function, ICAM-I, VCAM-I",

author = "F. Ermetici and Malavazos, {A. E.} and S. Corbetta and C. Eller-Vainicher and S. Cannav{\`o} and Corsi, {M. M.} and Bruno Ambrosi",

year = "2008",

month = may,

language = "English",

volume = "31",

pages = "389--392",

journal = "Journal of Endocrinological Investigation",

issn = "0391-4097",

publisher = "Springer International Publishing",

number = "5",

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T1 - Soluble adhesion molecules levels in patients with Cushing's syndrome before and after cure

AU - Ermetici, F.

AU - Malavazos, A. E.

AU - Corbetta, S.

AU - Eller-Vainicher, C.

AU - Cannavò, S.

AU - Corsi, M. M.

AU - Ambrosi, Bruno

PY - 2008/5

Y1 - 2008/5

N2 - Objective: Patients with Cushing's syndrome (CS) show a high prevalence of cardiovascular risk factors and atherosclerosis, persisting even after cure. Soluble intercellular adhesion molecule- I (sICAM-I) and vascular cell adhesion molecule-I (sVCAM-I) are surrogate markers of endothelial function involved in the initiation of atherosclerosis. This study aimed to evaluate sICAM-I and sVCAM-I levels in patients with CS before and after successful cure. Subjects and methods: sICAM-I and sVCAM-I levels were evaluated in 28 patients with active CS and in 12 patients with Cushing's disease (CD), 6-12 months after disease remission. Body mass index (BMI), blood pressure, glucose, serum lipids, ACTH, cortisol and urinary free cortisol (UFC) were measured in basal conditions in all patients. Results: At baseline, sICAM-I levels positively correlated with BMI (r=0.443, p

AB - Objective: Patients with Cushing's syndrome (CS) show a high prevalence of cardiovascular risk factors and atherosclerosis, persisting even after cure. Soluble intercellular adhesion molecule- I (sICAM-I) and vascular cell adhesion molecule-I (sVCAM-I) are surrogate markers of endothelial function involved in the initiation of atherosclerosis. This study aimed to evaluate sICAM-I and sVCAM-I levels in patients with CS before and after successful cure. Subjects and methods: sICAM-I and sVCAM-I levels were evaluated in 28 patients with active CS and in 12 patients with Cushing's disease (CD), 6-12 months after disease remission. Body mass index (BMI), blood pressure, glucose, serum lipids, ACTH, cortisol and urinary free cortisol (UFC) were measured in basal conditions in all patients. Results: At baseline, sICAM-I levels positively correlated with BMI (r=0.443, p

KW - Cardiovascular risk

KW - Cortisol

KW - Cushing's syndrome

KW - Endothelial function

KW - ICAM-I

KW - VCAM-I

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JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

SN - 0391-4097

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