Abstract
Objective: Patients with Cushing's syndrome (CS) show a high prevalence of cardiovascular risk factors and atherosclerosis, persisting even after cure. Soluble intercellular adhesion molecule- I (sICAM-I) and vascular cell adhesion molecule-I (sVCAM-I) are surrogate markers of endothelial function involved in the initiation of atherosclerosis. This study aimed to evaluate sICAM-I and sVCAM-I levels in patients with CS before and after successful cure. Subjects and methods: sICAM-I and sVCAM-I levels were evaluated in 28 patients with active CS and in 12 patients with Cushing's disease (CD), 6-12 months after disease remission. Body mass index (BMI), blood pressure, glucose, serum lipids, ACTH, cortisol and urinary free cortisol (UFC) were measured in basal conditions in all patients. Results: At baseline, sICAM-I levels positively correlated with BMI (r=0.443, p
Original language | English |
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Pages (from-to) | 389-392 |
Number of pages | 4 |
Journal | Journal of Endocrinological Investigation |
Volume | 31 |
Issue number | 5 |
Publication status | Published - May 2008 |
Keywords
- Cardiovascular risk
- Cortisol
- Cushing's syndrome
- Endothelial function
- ICAM-I
- VCAM-I
ASJC Scopus subject areas
- Endocrinology