Determinazione del CD138 solubile nel siero di pazienti affetti da mieloma multiplo IgD

Translated title of the contribution: Soluble CD138 concentrations in serum of patients with IgD myeloma

Umberto Basile, Francesca Gulli, Giovanni Cigliana, Sergio Storti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Syndecan-1, also known as CD138, is a proteoglycan expressed on plasma cell surface. In this paper we determined soluble CD138 (sCD138) in serum of two patients with IgD myeloma and emphasized the role of sCD138 in pathophysiology of monoclonal gammopathies through the regulation of B-lymphocyte malignancy growth, particularly in the IgD myeloma. Both studied patients, the first with IgDK and the second with IgDA monoclonal components, were positive for sCD138, with values of 305 kU/L and 360 kU/L, respectively. Our findings proved that in patients with IgD myeloma sCD138 concentrations are increased and could help to improve the diagnosis of this rare type of myeloma. Copyright originale

Original languageItalian
Pages (from-to)56-61
Number of pages6
JournalBiochimica Clinica
Volume35
Issue number1
Publication statusPublished - Feb 2011

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Immunoglobulin D
Serum
Syndecan-1
Paraproteinemias
Lymphocytes
Proteoglycans
Plasma Cells
B-Lymphocytes
Plasmas
Growth
Neoplasms

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology

Cite this

Determinazione del CD138 solubile nel siero di pazienti affetti da mieloma multiplo IgD. / Basile, Umberto; Gulli, Francesca; Cigliana, Giovanni; Storti, Sergio.

In: Biochimica Clinica, Vol. 35, No. 1, 02.2011, p. 56-61.

Research output: Contribution to journalArticle

Basile, Umberto ; Gulli, Francesca ; Cigliana, Giovanni ; Storti, Sergio. / Determinazione del CD138 solubile nel siero di pazienti affetti da mieloma multiplo IgD. In: Biochimica Clinica. 2011 ; Vol. 35, No. 1. pp. 56-61.
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