Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: Preliminary reference ranges

Michele Mussap, Elisabetta Puxeddu, Patrizia Burrai, Antonio Noto, Francesco Cibecchini, Marcella Testa, Melania Puddu, Giovanni Ottonello, Angelica Dessì, Roberta Irmesi, Elisabetta Dalla Gassa, Claudia Fanni, Vassilios Fanos

Research output: Contribution to journalArticlepeer-review

Abstract

Soluble CD14 subtype (sCD14-ST), also named presepsin, is a 13kDa truncated form of soluble CD14 (sCD14), consisting of 64 amino acid residues. Systemic inflammation and sepsis are characterized by an early, significant increase in sCD14-ST presepsin blood concentration and thus, this small polypeptide has been proposed as a novel, reliable biomarker for the management of sepsis. We enrolled twenty-six consecutive non-septic preterm newborns with gestational age (GA) between 26 and 36 weeks) admitted to NICU after the first day of life for various severe diseases. sCD14-ST presepsin was measure on whole blood samples by a rapid commercial available chemiluminescent enzyme immunoassay (CLEIA) based on a non-competitive CLEIA. The mean sCD14-ST presepsin blood level in 26 preterm newborns was 643.1ng/L, with a standard deviation (SD) of 303.8ng/L; the median value was 578ng/L. Our results clearly suggest no correlation between GA and sCD14-ST presepsin blood level between 26 and 36 weeks and thus it is reasonable to adopt a unique reference range for preterm newborns.

Original languageEnglish
Pages (from-to)51-53
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume25
Issue numberSUPPL. 5
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Neonatal sepsis
  • Preterm newborns
  • Reference ranges
  • Soluble CD14 subtype presepsin (sCD14-ST)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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