Abstract
The serum levels of some cytokines seem to correlate with outcome in Hodgkin's disease (HD) and may be helpful in formulating new and better prognostic systems. The aim of this study was to analyse the correlations between the serum levels of different cytokines and the clinico-hematological features suggestive of a worse prognosis. The study involved 31 pts with a 'de novo' diagnosis of HD (median age: 30 yrs; M/F: 13/18; stage I/II vs III/IV: 19/12; B symptoms: 12; bulky disease and extranodal disease: 9). The serum levels of sCD30, TNFα, TNF receptor I and II, IL6, IL6 receptor, IL10, sICAM-1 were evaluated at diagnosis, and correlated with gender, age (≤/> 30), stage (I-II vs III-IV), systemic symptoms, bulky disease, ESR ( 170 μg/dL), WBC counts (≤/> 15 x 10 9/L), prognostic scores (PS) according to Hasenclever ( 33.15 U/mL, TNFα > 29.71 pg/mL, IL6 > 12.43 pg/mL, TNF-RI > 3.23 ng/mL, IL6-R > 57 ng/mL) that significantly correlate with systemic symptoms, higher disease stages, ESR, serum copper, WBC counts and PS. Our study shows that high sCD30, TNFα, IL6 and TNF-RI levels are associated with advanced disease or a worse prognostic score. In the context of multiparametric HD staging, cytokine evaluation may be useful for identifying candidates for more intensive therapies.
| Original language | English |
|---|---|
| Pages (from-to) | 333-339 |
| Number of pages | 7 |
| Journal | Leukemia and Lymphoma |
| Volume | 37 |
| Issue number | 3-4 |
| Publication status | Published - 2000 |
Fingerprint
Keywords
- Advanced disease
- Hodgkin's disease
- Serum cytokines
- Worse prognosis
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Soluble cytokine levels correlate with the activity and clinical stage of Hodgkin's disease at diagnosis. / Vener, Claudia; Guffanti, Andrea; Pomati, Mauro; Colombi, Mariangela; Aliettt, Alessandra; Targia, Maria Luisa La; Bamonti-Catena, Fabrizia; Baldini, Luca.
In: Leukemia and Lymphoma, Vol. 37, No. 3-4, 2000, p. 333-339.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Soluble cytokine levels correlate with the activity and clinical stage of Hodgkin's disease at diagnosis
AU - Vener, Claudia
AU - Guffanti, Andrea
AU - Pomati, Mauro
AU - Colombi, Mariangela
AU - Aliettt, Alessandra
AU - Targia, Maria Luisa La
AU - Bamonti-Catena, Fabrizia
AU - Baldini, Luca
PY - 2000
Y1 - 2000
N2 - The serum levels of some cytokines seem to correlate with outcome in Hodgkin's disease (HD) and may be helpful in formulating new and better prognostic systems. The aim of this study was to analyse the correlations between the serum levels of different cytokines and the clinico-hematological features suggestive of a worse prognosis. The study involved 31 pts with a 'de novo' diagnosis of HD (median age: 30 yrs; M/F: 13/18; stage I/II vs III/IV: 19/12; B symptoms: 12; bulky disease and extranodal disease: 9). The serum levels of sCD30, TNFα, TNF receptor I and II, IL6, IL6 receptor, IL10, sICAM-1 were evaluated at diagnosis, and correlated with gender, age (≤/> 30), stage (I-II vs III-IV), systemic symptoms, bulky disease, ESR ( 170 μg/dL), WBC counts (≤/> 15 x 10 9/L), prognostic scores (PS) according to Hasenclever ( 33.15 U/mL, TNFα > 29.71 pg/mL, IL6 > 12.43 pg/mL, TNF-RI > 3.23 ng/mL, IL6-R > 57 ng/mL) that significantly correlate with systemic symptoms, higher disease stages, ESR, serum copper, WBC counts and PS. Our study shows that high sCD30, TNFα, IL6 and TNF-RI levels are associated with advanced disease or a worse prognostic score. In the context of multiparametric HD staging, cytokine evaluation may be useful for identifying candidates for more intensive therapies.
AB - The serum levels of some cytokines seem to correlate with outcome in Hodgkin's disease (HD) and may be helpful in formulating new and better prognostic systems. The aim of this study was to analyse the correlations between the serum levels of different cytokines and the clinico-hematological features suggestive of a worse prognosis. The study involved 31 pts with a 'de novo' diagnosis of HD (median age: 30 yrs; M/F: 13/18; stage I/II vs III/IV: 19/12; B symptoms: 12; bulky disease and extranodal disease: 9). The serum levels of sCD30, TNFα, TNF receptor I and II, IL6, IL6 receptor, IL10, sICAM-1 were evaluated at diagnosis, and correlated with gender, age (≤/> 30), stage (I-II vs III-IV), systemic symptoms, bulky disease, ESR ( 170 μg/dL), WBC counts (≤/> 15 x 10 9/L), prognostic scores (PS) according to Hasenclever ( 33.15 U/mL, TNFα > 29.71 pg/mL, IL6 > 12.43 pg/mL, TNF-RI > 3.23 ng/mL, IL6-R > 57 ng/mL) that significantly correlate with systemic symptoms, higher disease stages, ESR, serum copper, WBC counts and PS. Our study shows that high sCD30, TNFα, IL6 and TNF-RI levels are associated with advanced disease or a worse prognostic score. In the context of multiparametric HD staging, cytokine evaluation may be useful for identifying candidates for more intensive therapies.
KW - Advanced disease
KW - Hodgkin's disease
KW - Serum cytokines
KW - Worse prognosis
UR - http://www.scopus.com/inward/record.url?scp=0034107973&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034107973&partnerID=8YFLogxK
M3 - Article
C2 - 10752984
AN - SCOPUS:0034107973
VL - 37
SP - 333
EP - 339
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 3-4
ER -