Soluble E-selectin and intercellular adhesion molecule-1 plasma levels increase during acute myocardial infarction

Fabio Pellegatta, Giuseppe Pizzetti, Yan Lu, Antonella Radaelli, Daniela Pomes, Mauro Carlino, Carlo Meloni, Giuseppina Belotti, Laura Galli, Maria J. Vidal, Sergio L. Chierchia

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies have shown that adhesion molecules play a crucial role in leukocyte-endothelium interactions that occur during myocardial ischemia and reperfusion. We assessed the plasma levels of the soluble form of E- selectin (sE-selectin) and intercellular adhesion molecule-1 (sICAM-1) in 15 patients with acute myocardial infarction (AMI) and in 15 controls with chronic stable angina. In patients with AMI, the levels of sE-selectin and sICAM-I increased significantly during the first 8 h after infarction and subsequently decreased. Soluble E-selectin levels were inversely related to the peak plasma levels of creatine kinase-MB (CK-MB), and the time course of their appearance in plasma correlated with that of neutrophil count and plasma D-dimer. In individual patients, peak and mean sICAM-1 levels correlated respectively with plasma D-dimer concentrations and monocyte count, but no correlation were found when their time courses were analyzed. Eight hours after symptom onset, the mean plasma sE-selectin levels were higher in patients with AM1 than in those with stable angina, whereas no significant differences were found in mean plasma sICAM-1 levels between the two groups at every time analyzed. In the acute phase of MI (a) sE-selectin and sICAM-1 levels increase during the first 8 h and subsequently decrease; (b) the increase in sE-selectin probably reflects activation of endothelial cells, correlates with other inflammatory and coagulation parameters, and is inversely related to the degree of myocardial damage; and (c) sICAM-1 plasma levels do not represent a good marker of 'cell activation' because they reflect activation of different cells and may be affected by different conditions.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume30
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Myocardial infarction
  • Soluble E-selectin
  • Soluble ICAM-1

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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