Soluble E-selectin and soluble tumour necrosis factor receptor (60 kD) serum levels in patients with psoriasis

C. Bonifati, C. Bonifati, E. Trento, M. Carducci, G. Sacerdoti, A. Mussi, M. Fazio, F. Ameglio

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Increased tumour necrosis factor a has been found in psoriatic skin. This cytokine activates endothelial cclls and induces the membrane E-se-lectin molecule (E-selectin or endothelial leucocyte adhesion molecule I): The same cytokine is able to induce its own receptors. Since the soluble forms of E-selectin and tumour necrosis factor receptor (TNF-R. 60 kD) may be reliably measured in body fluids, these determinations have been performed in the sera of psoriatic patients. Objective: To evaluate endothelial activation in psoriatic patients. sE-selectin has been determined in patient sera and compared with those of a control group. sTNF-R (60 kD) was also measured in the same samples. Methods: Two commercially available enzyme immunoassay methods have been used to determine sE-selectin and sTNF-R (60 kD) in the sera ot 19 patients with plaque-type psoriasis; 22 healthy subjects were used as controls. Conclusions: Significantly increased amounts of sE-selectin serum levels were found in psoriatic patients as compared to healthy controls. Moreover, a direct correlation between sE-selectin and PASI scores was observed. On the contrary, sTNF-R (60 kD) serum levels presented no increases. These data suggest that sE-selectin serum levels are a reliable marker of disease activity in psoriatic patients.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalDermatology
Volume190
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • E-selectin, soluble
  • Endothelial leucocyte adhesion molecule 1, soluble
  • PASI score
  • Psoriasis
  • Serum
  • Tumour necrosis factor, receptor soluble

ASJC Scopus subject areas

  • Dermatology

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