Soluble E-selectin is not a marker of unstable coronary plaque in serum of patients with ischemic heart disease

Marcello Galvani, Donatella Ferrini, Filippo Ottani, Cristina Nanni, Alessandro Ramberti, Paolo Amboni, Laura Iamele, Arialdo Vernocchi, Francesca A. Nicolini

Research output: Contribution to journalArticlepeer-review

Abstract

Increased level of soluble cell adhesion molecules may be a marker for atherosclerosis and/or reflect complication of the atherosclerotic plaque. To test whether expression of cell adhesion molecules is more pronounced in unstable versus stable coronary plaques, we measured the serum level of soluble E-selectin (sE-selectin) in 99 consecutive patients admitted to the hospital for acute coronary syndromes (ACS) and in 61 patients with chronic coronary artery disease (CAD) using a commercially available ELISA kit. We also measured the sE-selectin concentration in 20 sex- and age-matched subjects without clinical evidence of atherosclerosis, who served as controls. The mean sE-selectin level was higher in both groups of patients compared with controls (ACS, 35.0 ± 23.4 ng/mL; chronic CAD, 32.9 ± 21.0 ng/mL; controls, 14.5 ± 6.6 ng/mL; one-way ANOVA, P = 0.001), but there was no difference between patients with ACS and chronic CAD. Furthermore, there was a trend (P = 0.08) toward a decrease in sE-selectin with an increase in the extent and severity of CAD. In patients with ACS, the in-hospital cardiac event rate was 8. Although mean sE-selectin concentration tended to be higher in patients with (49.2 ± 42.1 ng/mL) than in those without (33.8 ± 21.3 ng/mL) in-hospital cardiac events, the difference was not significant. In 53 patients with ACS, C-reactive protein was measured and showed no correlation with the sE-selectin concentration. These findings show that although sE-selectin concentration is elevated in the presence of clinically relevant atherosclerosis, it does not further increase during the unstable phase of the disease, indicating that sE-selectin is not a reliable indicator of a complicated atherosclerotic plaque.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalJournal of Thrombosis and Thrombolysis
Volume9
Issue number1
Publication statusPublished - 2000

Keywords

  • Acute coronary syndromes
  • Adhesion molecules
  • E-selectin

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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